Angioblast Derived from ES Cells Construct Blood Vessels and Ameliorate Diabetic Polyneuropathy in Mice
المؤلفون المشاركون
Himeno, Tatsuhito
Kamiya, Hideki
Naruse, Keiko
Cheng, Zhao
Kondo, Masaki
Okawa, Tetsuji
Fujiya, Atsushi
Suzuki, Hirohiko
Hamada, Yoji
Oiso, Yutaka
Nakamura, Jiro
Shibata, Taiga
Kato, Jiro
Kito, Tetsutaro
Isobe, Ken-ichi
Ito, Sachiko
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-17، 17ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-04-21
دولة النشر
مصر
عدد الصفحات
17
التخصصات الرئيسية
الملخص EN
Background.
Although numerous reports addressing pathological involvements of diabetic polyneuropathy have been conducted, a universally effective treatment of diabetic polyneuropathy has not yet been established.
Recently, regenerative medicine studies in diabetic polyneuropathy using somatic stem/progenitor cell have been reported.
However, the effectiveness of these cell transplantations was restricted because of their functional and numerical impairment in diabetic objects.
Here, we investigated the efficacy of treatment for diabetic polyneuropathy using angioblast-like cells derived from mouse embryonic stem cells.
Methods and Results.
Angioblast-like cells were obtained from mouse embryonic stem cells and transplantation of these cells improved several physiological impairments in diabetic polyneuropathy: hypoalgesia, delayed nerve conduction velocities, and reduced blood flow in sciatic nerve and plantar skin.
Furthermore, pathologically, the capillary number to muscle fiber ratios were increased in skeletal muscles of transplanted hindlimbs, and intraepidermal nerve fiber densities were ameliorated in transplanted plantar skin.
Transplanted cells maintained their viabilities and differentiated to endothelial cells and smooth muscle cells around the injection sites.
Moreover, several transplanted cells constructed chimeric blood vessels with recipient cells.
Conclusions.
These results suggest that transplantation of angioblast like cells induced from embryonic stem cells appears to be a novel therapeutic strategy for diabetic polyneuropathy.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Himeno, Tatsuhito& Kamiya, Hideki& Naruse, Keiko& Cheng, Zhao& Ito, Sachiko& Shibata, Taiga…[et al.]. 2015. Angioblast Derived from ES Cells Construct Blood Vessels and Ameliorate Diabetic Polyneuropathy in Mice. Journal of Diabetes Research،Vol. 2015, no. 2015, pp.1-17.
https://search.emarefa.net/detail/BIM-1067864
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Himeno, Tatsuhito…[et al.]. Angioblast Derived from ES Cells Construct Blood Vessels and Ameliorate Diabetic Polyneuropathy in Mice. Journal of Diabetes Research No. 2015 (2015), pp.1-17.
https://search.emarefa.net/detail/BIM-1067864
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Himeno, Tatsuhito& Kamiya, Hideki& Naruse, Keiko& Cheng, Zhao& Ito, Sachiko& Shibata, Taiga…[et al.]. Angioblast Derived from ES Cells Construct Blood Vessels and Ameliorate Diabetic Polyneuropathy in Mice. Journal of Diabetes Research. 2015. Vol. 2015, no. 2015, pp.1-17.
https://search.emarefa.net/detail/BIM-1067864
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1067864
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر