Angioblast Derived from ES Cells Construct Blood Vessels and Ameliorate Diabetic Polyneuropathy in Mice
Joint Authors
Himeno, Tatsuhito
Kamiya, Hideki
Naruse, Keiko
Cheng, Zhao
Kondo, Masaki
Okawa, Tetsuji
Fujiya, Atsushi
Suzuki, Hirohiko
Hamada, Yoji
Oiso, Yutaka
Nakamura, Jiro
Shibata, Taiga
Kato, Jiro
Kito, Tetsutaro
Isobe, Ken-ichi
Ito, Sachiko
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-21
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
Background.
Although numerous reports addressing pathological involvements of diabetic polyneuropathy have been conducted, a universally effective treatment of diabetic polyneuropathy has not yet been established.
Recently, regenerative medicine studies in diabetic polyneuropathy using somatic stem/progenitor cell have been reported.
However, the effectiveness of these cell transplantations was restricted because of their functional and numerical impairment in diabetic objects.
Here, we investigated the efficacy of treatment for diabetic polyneuropathy using angioblast-like cells derived from mouse embryonic stem cells.
Methods and Results.
Angioblast-like cells were obtained from mouse embryonic stem cells and transplantation of these cells improved several physiological impairments in diabetic polyneuropathy: hypoalgesia, delayed nerve conduction velocities, and reduced blood flow in sciatic nerve and plantar skin.
Furthermore, pathologically, the capillary number to muscle fiber ratios were increased in skeletal muscles of transplanted hindlimbs, and intraepidermal nerve fiber densities were ameliorated in transplanted plantar skin.
Transplanted cells maintained their viabilities and differentiated to endothelial cells and smooth muscle cells around the injection sites.
Moreover, several transplanted cells constructed chimeric blood vessels with recipient cells.
Conclusions.
These results suggest that transplantation of angioblast like cells induced from embryonic stem cells appears to be a novel therapeutic strategy for diabetic polyneuropathy.
American Psychological Association (APA)
Himeno, Tatsuhito& Kamiya, Hideki& Naruse, Keiko& Cheng, Zhao& Ito, Sachiko& Shibata, Taiga…[et al.]. 2015. Angioblast Derived from ES Cells Construct Blood Vessels and Ameliorate Diabetic Polyneuropathy in Mice. Journal of Diabetes Research،Vol. 2015, no. 2015, pp.1-17.
https://search.emarefa.net/detail/BIM-1067864
Modern Language Association (MLA)
Himeno, Tatsuhito…[et al.]. Angioblast Derived from ES Cells Construct Blood Vessels and Ameliorate Diabetic Polyneuropathy in Mice. Journal of Diabetes Research No. 2015 (2015), pp.1-17.
https://search.emarefa.net/detail/BIM-1067864
American Medical Association (AMA)
Himeno, Tatsuhito& Kamiya, Hideki& Naruse, Keiko& Cheng, Zhao& Ito, Sachiko& Shibata, Taiga…[et al.]. Angioblast Derived from ES Cells Construct Blood Vessels and Ameliorate Diabetic Polyneuropathy in Mice. Journal of Diabetes Research. 2015. Vol. 2015, no. 2015, pp.1-17.
https://search.emarefa.net/detail/BIM-1067864
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1067864