Characterization of the Prediabetic State in a Novel Rat Model of Type 2 Diabetes, the ZFDM Rat
المؤلفون المشاركون
Gheni, Ghupurjan
Beppu, Masayuki
Yamaguchi, Takuro
Kawabata, Ayako
Hoshino, Yoshikazu
Yokoi, Norihide
Hidaka, Shihomi
Hoshino, Masayuki
Seino, Susumu
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-04-16
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
We recently established a novel animal model of obese type 2 diabetes (T2D), the Zucker fatty diabetes mellitus (ZFDM) rat strain harboring the fatty mutation (fa) in the leptin receptor gene.
Here we performed a phenotypic characterization of the strain, focusing mainly on the prediabetic state.
At 6–8 weeks of age, fa/fa male rats exhibited mild glucose intolerance and severe insulin resistance.
Although basal insulin secretion was remarkably high in the isolated pancreatic islets, the responses to both glucose stimulation and the incretin GLP-1 were retained.
At 10–12 weeks of age, fa/fa male rats exhibited marked glucose intolerance as well as severe insulin resistance similar to that at the earlier age.
In the pancreatic islets, the insulin secretory response to glucose stimulation was maintained but the response to the incretin was diminished.
In nondiabetic Zucker fatty (ZF) rats, the insulin secretory responses to both glucose stimulation and the incretin in the pancreatic islets were similar to those of ZFDM rats.
As islet architecture was destroyed with age in ZFDM rats, a combination of severe insulin resistance, diminished insulin secretory response to incretin, and intrinsic fragility of the islets may cause the development of T2D in this strain.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Gheni, Ghupurjan& Yokoi, Norihide& Beppu, Masayuki& Yamaguchi, Takuro& Hidaka, Shihomi& Kawabata, Ayako…[et al.]. 2015. Characterization of the Prediabetic State in a Novel Rat Model of Type 2 Diabetes, the ZFDM Rat. Journal of Diabetes Research،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1067865
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Gheni, Ghupurjan…[et al.]. Characterization of the Prediabetic State in a Novel Rat Model of Type 2 Diabetes, the ZFDM Rat. Journal of Diabetes Research No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1067865
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Gheni, Ghupurjan& Yokoi, Norihide& Beppu, Masayuki& Yamaguchi, Takuro& Hidaka, Shihomi& Kawabata, Ayako…[et al.]. Characterization of the Prediabetic State in a Novel Rat Model of Type 2 Diabetes, the ZFDM Rat. Journal of Diabetes Research. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1067865
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1067865
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر