Characterization of the Prediabetic State in a Novel Rat Model of Type 2 Diabetes, the ZFDM Rat

Joint Authors

Gheni, Ghupurjan
Beppu, Masayuki
Yamaguchi, Takuro
Kawabata, Ayako
Hoshino, Yoshikazu
Yokoi, Norihide
Hidaka, Shihomi
Hoshino, Masayuki
Seino, Susumu

Source

Journal of Diabetes Research

Issue

Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2015-04-16

Country of Publication

Egypt

No. of Pages

8

Main Subjects

Diseases
Medicine

Abstract EN

We recently established a novel animal model of obese type 2 diabetes (T2D), the Zucker fatty diabetes mellitus (ZFDM) rat strain harboring the fatty mutation (fa) in the leptin receptor gene.

Here we performed a phenotypic characterization of the strain, focusing mainly on the prediabetic state.

At 6–8 weeks of age, fa/fa male rats exhibited mild glucose intolerance and severe insulin resistance.

Although basal insulin secretion was remarkably high in the isolated pancreatic islets, the responses to both glucose stimulation and the incretin GLP-1 were retained.

At 10–12 weeks of age, fa/fa male rats exhibited marked glucose intolerance as well as severe insulin resistance similar to that at the earlier age.

In the pancreatic islets, the insulin secretory response to glucose stimulation was maintained but the response to the incretin was diminished.

In nondiabetic Zucker fatty (ZF) rats, the insulin secretory responses to both glucose stimulation and the incretin in the pancreatic islets were similar to those of ZFDM rats.

As islet architecture was destroyed with age in ZFDM rats, a combination of severe insulin resistance, diminished insulin secretory response to incretin, and intrinsic fragility of the islets may cause the development of T2D in this strain.

American Psychological Association (APA)

Gheni, Ghupurjan& Yokoi, Norihide& Beppu, Masayuki& Yamaguchi, Takuro& Hidaka, Shihomi& Kawabata, Ayako…[et al.]. 2015. Characterization of the Prediabetic State in a Novel Rat Model of Type 2 Diabetes, the ZFDM Rat. Journal of Diabetes Research،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1067865

Modern Language Association (MLA)

Gheni, Ghupurjan…[et al.]. Characterization of the Prediabetic State in a Novel Rat Model of Type 2 Diabetes, the ZFDM Rat. Journal of Diabetes Research No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1067865

American Medical Association (AMA)

Gheni, Ghupurjan& Yokoi, Norihide& Beppu, Masayuki& Yamaguchi, Takuro& Hidaka, Shihomi& Kawabata, Ayako…[et al.]. Characterization of the Prediabetic State in a Novel Rat Model of Type 2 Diabetes, the ZFDM Rat. Journal of Diabetes Research. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1067865

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1067865