Rat Models of Diet-Induced Obesity and High FatLow Dose Streptozotocin Type 2 Diabetes: Effect of Reversal of High Fat Diet Compared to Treatment with Enalapril or Menhaden Oil on Glucose Utilization and Neuropathic Endpoints
المؤلفون المشاركون
Yorek, Mark A.
Davidson, Eric P.
Holmes, Amey
Coppey, Lawrence J.
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-07-02
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
We examined whether reversal of high fat diet, stimulating weight loss, compared to two treatments previously shown to have beneficial effects, could improve glucose utilization and peripheral neuropathy in animal models of obesity and type 2 diabetes.
Rats were fed a high fat diet and treated with a low dose of streptozotocin to create models of diet induced obesity or type 2 diabetes, respectively.
Afterwards, rats were transferred to a normal diet or treated with enalapril or dietary enrichment with menhaden oil for 12 weeks.
Obesity and to a greater extent type 2 diabetes were associated with impaired glucose utilization and peripheral neuropathy.
Placing obese rats on a normal diet improved glucose utilization.
Steatosis but not peripheral neuropathy was improved after placing obese or diabetic rats on a normal diet.
Treating obese and diabetic rats with enalapril or a menhaden oil enriched diet generally improved peripheral neuropathy endpoints.
In summary, dietary improvement with weight loss in obese or type 2 diabetic rats was not sufficient to correct peripheral neuropathy.
These results further stress the need for discovery of a comprehensive treatment for peripheral neuropathy.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Holmes, Amey& Coppey, Lawrence J.& Davidson, Eric P.& Yorek, Mark A.. 2015. Rat Models of Diet-Induced Obesity and High FatLow Dose Streptozotocin Type 2 Diabetes: Effect of Reversal of High Fat Diet Compared to Treatment with Enalapril or Menhaden Oil on Glucose Utilization and Neuropathic Endpoints. Journal of Diabetes Research،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1067874
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Holmes, Amey…[et al.]. Rat Models of Diet-Induced Obesity and High FatLow Dose Streptozotocin Type 2 Diabetes: Effect of Reversal of High Fat Diet Compared to Treatment with Enalapril or Menhaden Oil on Glucose Utilization and Neuropathic Endpoints. Journal of Diabetes Research No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1067874
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Holmes, Amey& Coppey, Lawrence J.& Davidson, Eric P.& Yorek, Mark A.. Rat Models of Diet-Induced Obesity and High FatLow Dose Streptozotocin Type 2 Diabetes: Effect of Reversal of High Fat Diet Compared to Treatment with Enalapril or Menhaden Oil on Glucose Utilization and Neuropathic Endpoints. Journal of Diabetes Research. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1067874
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1067874
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر