Rat Models of Diet-Induced Obesity and High FatLow Dose Streptozotocin Type 2 Diabetes: Effect of Reversal of High Fat Diet Compared to Treatment with Enalapril or Menhaden Oil on Glucose Utilization and Neuropathic Endpoints
Joint Authors
Yorek, Mark A.
Davidson, Eric P.
Holmes, Amey
Coppey, Lawrence J.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-07-02
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
We examined whether reversal of high fat diet, stimulating weight loss, compared to two treatments previously shown to have beneficial effects, could improve glucose utilization and peripheral neuropathy in animal models of obesity and type 2 diabetes.
Rats were fed a high fat diet and treated with a low dose of streptozotocin to create models of diet induced obesity or type 2 diabetes, respectively.
Afterwards, rats were transferred to a normal diet or treated with enalapril or dietary enrichment with menhaden oil for 12 weeks.
Obesity and to a greater extent type 2 diabetes were associated with impaired glucose utilization and peripheral neuropathy.
Placing obese rats on a normal diet improved glucose utilization.
Steatosis but not peripheral neuropathy was improved after placing obese or diabetic rats on a normal diet.
Treating obese and diabetic rats with enalapril or a menhaden oil enriched diet generally improved peripheral neuropathy endpoints.
In summary, dietary improvement with weight loss in obese or type 2 diabetic rats was not sufficient to correct peripheral neuropathy.
These results further stress the need for discovery of a comprehensive treatment for peripheral neuropathy.
American Psychological Association (APA)
Holmes, Amey& Coppey, Lawrence J.& Davidson, Eric P.& Yorek, Mark A.. 2015. Rat Models of Diet-Induced Obesity and High FatLow Dose Streptozotocin Type 2 Diabetes: Effect of Reversal of High Fat Diet Compared to Treatment with Enalapril or Menhaden Oil on Glucose Utilization and Neuropathic Endpoints. Journal of Diabetes Research،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1067874
Modern Language Association (MLA)
Holmes, Amey…[et al.]. Rat Models of Diet-Induced Obesity and High FatLow Dose Streptozotocin Type 2 Diabetes: Effect of Reversal of High Fat Diet Compared to Treatment with Enalapril or Menhaden Oil on Glucose Utilization and Neuropathic Endpoints. Journal of Diabetes Research No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1067874
American Medical Association (AMA)
Holmes, Amey& Coppey, Lawrence J.& Davidson, Eric P.& Yorek, Mark A.. Rat Models of Diet-Induced Obesity and High FatLow Dose Streptozotocin Type 2 Diabetes: Effect of Reversal of High Fat Diet Compared to Treatment with Enalapril or Menhaden Oil on Glucose Utilization and Neuropathic Endpoints. Journal of Diabetes Research. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1067874
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1067874