Ileal Interposition in Rats with Experimental Type 2 Like Diabetes Improves Glycemic Control Independently of Glucose Absorption
المؤلفون المشاركون
Jurowich, Christian Ferdinand
Otto, Christoph
Rikkala, Prashanth Reddy
Wagner, Nicole
Vrhovac, Ivana
Sabolić, Ivan
Koepsell, Hermann
Germer, C.
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-06-22
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Bariatric operations in obese patients with type 2 diabetes often improve diabetes before weight loss is observed.
In patients mainly Roux-en-Y-gastric bypass with partial stomach resection is performed.
Duodenojejunal bypass (DJB) and ileal interposition (IIP) are employed in animal experiments.
Due to increased glucose exposition of L-cells located in distal ileum, all bariatric surgery procedures lead to higher secretion of antidiabetic glucagon like peptide-1 (GLP-1) after glucose gavage.
After DJB also downregulation of Na+-d-glucose cotransporter SGLT1 was observed.
This suggested a direct contribution of decreased glucose absorption to the antidiabetic effect of bariatric surgery.
To investigate whether glucose absorption is also decreased after IIP, we induced diabetes with decreased glucose tolerance and insulin sensitivity in male rats and investigated effects of IIP on diabetes and SGLT1.
After IIP, we observed weight-independent improvement of glucose tolerance, increased insulin sensitivity, and increased plasma GLP-1 after glucose gavage.
The interposed ileum was increased in diameter and showed increased length of villi, hyperplasia of the epithelial layer, and increased number of L-cells.
The amount of SGLT1-mediated glucose uptake in interposed ileum was increased 2-fold reaching the same level as in jejunum.
Thus, improvement of glycemic control by bariatric surgery does not require decreased glucose absorption.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Jurowich, Christian Ferdinand& Otto, Christoph& Rikkala, Prashanth Reddy& Wagner, Nicole& Vrhovac, Ivana& Sabolić, Ivan…[et al.]. 2015. Ileal Interposition in Rats with Experimental Type 2 Like Diabetes Improves Glycemic Control Independently of Glucose Absorption. Journal of Diabetes Research،Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1067924
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Jurowich, Christian Ferdinand…[et al.]. Ileal Interposition in Rats with Experimental Type 2 Like Diabetes Improves Glycemic Control Independently of Glucose Absorption. Journal of Diabetes Research No. 2015 (2015), pp.1-14.
https://search.emarefa.net/detail/BIM-1067924
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Jurowich, Christian Ferdinand& Otto, Christoph& Rikkala, Prashanth Reddy& Wagner, Nicole& Vrhovac, Ivana& Sabolić, Ivan…[et al.]. Ileal Interposition in Rats with Experimental Type 2 Like Diabetes Improves Glycemic Control Independently of Glucose Absorption. Journal of Diabetes Research. 2015. Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1067924
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1067924
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر