Ileal Interposition in Rats with Experimental Type 2 Like Diabetes Improves Glycemic Control Independently of Glucose Absorption
Joint Authors
Jurowich, Christian Ferdinand
Otto, Christoph
Rikkala, Prashanth Reddy
Wagner, Nicole
Vrhovac, Ivana
Sabolić, Ivan
Koepsell, Hermann
Germer, C.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-22
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Bariatric operations in obese patients with type 2 diabetes often improve diabetes before weight loss is observed.
In patients mainly Roux-en-Y-gastric bypass with partial stomach resection is performed.
Duodenojejunal bypass (DJB) and ileal interposition (IIP) are employed in animal experiments.
Due to increased glucose exposition of L-cells located in distal ileum, all bariatric surgery procedures lead to higher secretion of antidiabetic glucagon like peptide-1 (GLP-1) after glucose gavage.
After DJB also downregulation of Na+-d-glucose cotransporter SGLT1 was observed.
This suggested a direct contribution of decreased glucose absorption to the antidiabetic effect of bariatric surgery.
To investigate whether glucose absorption is also decreased after IIP, we induced diabetes with decreased glucose tolerance and insulin sensitivity in male rats and investigated effects of IIP on diabetes and SGLT1.
After IIP, we observed weight-independent improvement of glucose tolerance, increased insulin sensitivity, and increased plasma GLP-1 after glucose gavage.
The interposed ileum was increased in diameter and showed increased length of villi, hyperplasia of the epithelial layer, and increased number of L-cells.
The amount of SGLT1-mediated glucose uptake in interposed ileum was increased 2-fold reaching the same level as in jejunum.
Thus, improvement of glycemic control by bariatric surgery does not require decreased glucose absorption.
American Psychological Association (APA)
Jurowich, Christian Ferdinand& Otto, Christoph& Rikkala, Prashanth Reddy& Wagner, Nicole& Vrhovac, Ivana& Sabolić, Ivan…[et al.]. 2015. Ileal Interposition in Rats with Experimental Type 2 Like Diabetes Improves Glycemic Control Independently of Glucose Absorption. Journal of Diabetes Research،Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1067924
Modern Language Association (MLA)
Jurowich, Christian Ferdinand…[et al.]. Ileal Interposition in Rats with Experimental Type 2 Like Diabetes Improves Glycemic Control Independently of Glucose Absorption. Journal of Diabetes Research No. 2015 (2015), pp.1-14.
https://search.emarefa.net/detail/BIM-1067924
American Medical Association (AMA)
Jurowich, Christian Ferdinand& Otto, Christoph& Rikkala, Prashanth Reddy& Wagner, Nicole& Vrhovac, Ivana& Sabolić, Ivan…[et al.]. Ileal Interposition in Rats with Experimental Type 2 Like Diabetes Improves Glycemic Control Independently of Glucose Absorption. Journal of Diabetes Research. 2015. Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1067924
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1067924