GDF-15 as a Target and Biomarker for Diabetes and Cardiovascular Diseases: A Translational Prospective
المؤلفون المشاركون
Adela, Ramu
Banerjee, Sanjay K.
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-07-27
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Growth differentiation factor-15 (GDF-15) is a stress responsive cytokine.
It is highly expressed in cardiomyocytes, adipocytes, macrophages, endothelial cells, and vascular smooth muscle cells in normal and pathological condition.
GDF-15 increases during tissue injury and inflammatory states and is associated with cardiometabolic risk.
Increased GDF-15 levels are associated with cardiovascular diseases such as hypertrophy, heart failure, atherosclerosis, endothelial dysfunction, obesity, insulin resistance, diabetes, and chronic kidney diseases in diabetes.
Increased GDF-15 level is linked with the progression and prognosis of the disease condition.
Age, smoking, and environmental factors are other risk factors that may increase GDF-15 level.
Most of the scientific studies reported that GDF-15 plays a protective role in different tissues.
However, few reports show that the deficiency of GDF-15 is beneficial against vascular injury and inflammation.
GDF-15 protects heart, adipose tissue, and endothelial cells by inhibiting JNK (c-Jun N-terminal kinase), Bad (Bcl-2-associated death promoter), and EGFR (epidermal growth factor receptor) and activating Smad, eNOS, PI3K, and AKT signaling pathways.
The present review describes the different animal and clinical studies and patent updates of GDF-15 in diabetes and cardiovascular diseases.
It is a challenge for the scientific community to use GDF-15 information for patient monitoring, clinical decision-making, and replacement of current treatment strategies for diabetic and cardiovascular diseases.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Adela, Ramu& Banerjee, Sanjay K.. 2015. GDF-15 as a Target and Biomarker for Diabetes and Cardiovascular Diseases: A Translational Prospective. Journal of Diabetes Research،Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1067925
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Adela, Ramu& Banerjee, Sanjay K.. GDF-15 as a Target and Biomarker for Diabetes and Cardiovascular Diseases: A Translational Prospective. Journal of Diabetes Research No. 2015 (2015), pp.1-14.
https://search.emarefa.net/detail/BIM-1067925
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Adela, Ramu& Banerjee, Sanjay K.. GDF-15 as a Target and Biomarker for Diabetes and Cardiovascular Diseases: A Translational Prospective. Journal of Diabetes Research. 2015. Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1067925
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1067925
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر