Nutrient Induced Type 2 and Chemical Induced Type 1 Experimental Diabetes Differently Modulate Gastric GLP-1 Receptor Expression
المؤلفون المشاركون
Bloch, Olga
Broide, Efrat
Ben-Yehudah, Gilad
Cantrell, Dror
Shirin, Haim
Rapoport, Micha J.
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-03-29
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
T2DM patients demonstrate reduced GLP-1 receptor (GLP-1R) expression in their gastric glands.
Whether induced T2DM and T1DM differently affect the gastric GLP-1R expression is not known.
This study assessed extrapancreatic GLP-1R system in glandular stomach of rodents with different types of experimental diabetes.
T2DM and T1DM were induced in Psammomys obesus (PO) by high-energy (HE) diet and by streptozotocin (STZ) in Sprague Dawly (SD) rats, respectively.
GLP-1R expression was determined in glandular stomach by RT PCR and immunohistomorphological analysis.
The mRNA expression and cellular association of the GLP-1R in principal glands were similar in control PO and SD rats.
However, nutrient and chemical induced diabetes resulted in opposite alterations of glandular GLP-1R expression.
Diabetic PO demonstrated increased GLP-1R mRNA expression, intensity of cellular GLP-1R immunostaining, and frequency of GLP-1R positive cells in the neck area of principal glands compared with controls.
In contrast, SD diabetic rats demonstrated decreased GLP-1 mRNA, cellular GLP-1R immunoreactivity, and frequency of GLP-1R immunoreactive cells in the neck area compared with controls.
In conclusion, nutrient and chemical induced experimental diabetes result in distinct opposite alterations of GLP-1R expression in glandular stomach.
These results suggest that induced T1DM and T2DM may differently modulate GLP-1R system in enteropancreatic axis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Bloch, Olga& Broide, Efrat& Ben-Yehudah, Gilad& Cantrell, Dror& Shirin, Haim& Rapoport, Micha J.. 2015. Nutrient Induced Type 2 and Chemical Induced Type 1 Experimental Diabetes Differently Modulate Gastric GLP-1 Receptor Expression. Journal of Diabetes Research،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1067948
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Bloch, Olga…[et al.]. Nutrient Induced Type 2 and Chemical Induced Type 1 Experimental Diabetes Differently Modulate Gastric GLP-1 Receptor Expression. Journal of Diabetes Research No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1067948
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Bloch, Olga& Broide, Efrat& Ben-Yehudah, Gilad& Cantrell, Dror& Shirin, Haim& Rapoport, Micha J.. Nutrient Induced Type 2 and Chemical Induced Type 1 Experimental Diabetes Differently Modulate Gastric GLP-1 Receptor Expression. Journal of Diabetes Research. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1067948
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1067948
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر