Association Analysis of Genetic Variants with Type 2 Diabetes in a Mongolian Population in China
المؤلفون المشاركون
Bai, Haihua
Liu, Haiping
Suyalatu, Suyalatu
Guo, Xiaosen
Chu, Shandan
Chen, Ying
Lan, Tianming
Borjigin, Burenbatu
Orlov, Yuriy L.
Posukh, Olga L.
Yang, Xiuqin
Guilan, Guilan
Osipova, Ludmila P.
Wu, Qizhu
Narisu, Narisu
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-07-28
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
The large scale genome wide association studies (GWAS) have identified approximately 80 single nucleotide polymorphisms (SNPs) conferring susceptibility to type 2 diabetes (T2D).
However, most of these loci have not been replicated in diverse populations and much genetic heterogeneity has been observed across ethnic groups.
We tested 28 SNPs previously found to be associated with T2D by GWAS in a Mongolian sample of Northern China (497 diagnosed with T2D and 469 controls) for association with T2D and diabetes related quantitative traits.
We replicated T2D association of 11 SNPs, namely, rs7578326 (IRS1), rs1531343 (HMGA2), rs8042680 (PRC1), rs7578597 (THADA), rs1333051 (CDKN2), rs6723108 (TMEM163), rs163182 and rs2237897 (KCNQ1), rs1387153 (MTNR1B), rs243021 (BCL11A), and rs10229583 (PAX4) in our sample.
Further, we showed that risk allele of the strongest T2D associated SNP in our sample, rs757832 (IRS1), is associated with increased level of TG.
We observed substantial difference of T2D risk allele frequency between the Mongolian sample and the 1000G Caucasian sample for a few SNPs, including rs6723108 (TMEM163) whose risk allele reaches near fixation in the Mongolian sample.
Further study of genetic architecture of these variants in susceptibility of T2D is needed to understand the role of these variants in heterogeneous populations.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Bai, Haihua& Liu, Haiping& Suyalatu, Suyalatu& Guo, Xiaosen& Chu, Shandan& Chen, Ying…[et al.]. 2015. Association Analysis of Genetic Variants with Type 2 Diabetes in a Mongolian Population in China. Journal of Diabetes Research،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1067958
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Bai, Haihua…[et al.]. Association Analysis of Genetic Variants with Type 2 Diabetes in a Mongolian Population in China. Journal of Diabetes Research No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1067958
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Bai, Haihua& Liu, Haiping& Suyalatu, Suyalatu& Guo, Xiaosen& Chu, Shandan& Chen, Ying…[et al.]. Association Analysis of Genetic Variants with Type 2 Diabetes in a Mongolian Population in China. Journal of Diabetes Research. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1067958
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1067958
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر