Association Analysis of Genetic Variants with Type 2 Diabetes in a Mongolian Population in China
Joint Authors
Bai, Haihua
Liu, Haiping
Suyalatu, Suyalatu
Guo, Xiaosen
Chu, Shandan
Chen, Ying
Lan, Tianming
Borjigin, Burenbatu
Orlov, Yuriy L.
Posukh, Olga L.
Yang, Xiuqin
Guilan, Guilan
Osipova, Ludmila P.
Wu, Qizhu
Narisu, Narisu
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-07-28
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The large scale genome wide association studies (GWAS) have identified approximately 80 single nucleotide polymorphisms (SNPs) conferring susceptibility to type 2 diabetes (T2D).
However, most of these loci have not been replicated in diverse populations and much genetic heterogeneity has been observed across ethnic groups.
We tested 28 SNPs previously found to be associated with T2D by GWAS in a Mongolian sample of Northern China (497 diagnosed with T2D and 469 controls) for association with T2D and diabetes related quantitative traits.
We replicated T2D association of 11 SNPs, namely, rs7578326 (IRS1), rs1531343 (HMGA2), rs8042680 (PRC1), rs7578597 (THADA), rs1333051 (CDKN2), rs6723108 (TMEM163), rs163182 and rs2237897 (KCNQ1), rs1387153 (MTNR1B), rs243021 (BCL11A), and rs10229583 (PAX4) in our sample.
Further, we showed that risk allele of the strongest T2D associated SNP in our sample, rs757832 (IRS1), is associated with increased level of TG.
We observed substantial difference of T2D risk allele frequency between the Mongolian sample and the 1000G Caucasian sample for a few SNPs, including rs6723108 (TMEM163) whose risk allele reaches near fixation in the Mongolian sample.
Further study of genetic architecture of these variants in susceptibility of T2D is needed to understand the role of these variants in heterogeneous populations.
American Psychological Association (APA)
Bai, Haihua& Liu, Haiping& Suyalatu, Suyalatu& Guo, Xiaosen& Chu, Shandan& Chen, Ying…[et al.]. 2015. Association Analysis of Genetic Variants with Type 2 Diabetes in a Mongolian Population in China. Journal of Diabetes Research،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1067958
Modern Language Association (MLA)
Bai, Haihua…[et al.]. Association Analysis of Genetic Variants with Type 2 Diabetes in a Mongolian Population in China. Journal of Diabetes Research No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1067958
American Medical Association (AMA)
Bai, Haihua& Liu, Haiping& Suyalatu, Suyalatu& Guo, Xiaosen& Chu, Shandan& Chen, Ying…[et al.]. Association Analysis of Genetic Variants with Type 2 Diabetes in a Mongolian Population in China. Journal of Diabetes Research. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1067958
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1067958