Longitudinal Analysis of Adiponectin through 20-Year Type 1 Diabetes Duration
المؤلفون المشاركون
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-04-09
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Little information exists on the trajectory and determinants of adiponectin, a possible insulin sensitizer and marker for inflammation and endothelial function, across the duration of type 1 diabetes.
The Wisconsin Diabetes Registry Study followed an incident cohort ≤30 years of age when diagnosed with type 1 diabetes during 1987–1992 up to 20-year duration.
Adiponectin was concurrently and retrospectively (from samples frozen at −80°C) measured for those participating in a 20-year exam ( n = 304 ), during 2007–2011.
Adiponectin levels were higher in females, declined through adolescence, and increased with age thereafter.
Lower levels were associated with greater body weight and waist circumference and with higher insulin dose, especially at longer diabetes durations.
Higher levels were associated with higher HbA1c and, at longer durations, with higher albumin-creatinine ratio.
Adiponectin levels showed consistency within individuals that was not explained by these factors.
We conclude that markers for insulin resistance are associated with lower adiponectin, and markers for potential microvascular complications are associated with higher adiponectin.
The previously reported relationship with HbA1c remains largely unexplained.
Additional individual specific factors likely also influence adiponectin level.
The relationship between adiponectin and urinary protein excretion may enable identification of those predisposed to kidney disease earlier in type 1 diabetes.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
LeCaire, Tamara J.& Palta, Mari. 2015. Longitudinal Analysis of Adiponectin through 20-Year Type 1 Diabetes Duration. Journal of Diabetes Research،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1067987
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
LeCaire, Tamara J.& Palta, Mari. Longitudinal Analysis of Adiponectin through 20-Year Type 1 Diabetes Duration. Journal of Diabetes Research No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1067987
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
LeCaire, Tamara J.& Palta, Mari. Longitudinal Analysis of Adiponectin through 20-Year Type 1 Diabetes Duration. Journal of Diabetes Research. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1067987
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1067987
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر