Longitudinal Analysis of Adiponectin through 20-Year Type 1 Diabetes Duration
Joint Authors
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-09
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Little information exists on the trajectory and determinants of adiponectin, a possible insulin sensitizer and marker for inflammation and endothelial function, across the duration of type 1 diabetes.
The Wisconsin Diabetes Registry Study followed an incident cohort ≤30 years of age when diagnosed with type 1 diabetes during 1987–1992 up to 20-year duration.
Adiponectin was concurrently and retrospectively (from samples frozen at −80°C) measured for those participating in a 20-year exam ( n = 304 ), during 2007–2011.
Adiponectin levels were higher in females, declined through adolescence, and increased with age thereafter.
Lower levels were associated with greater body weight and waist circumference and with higher insulin dose, especially at longer diabetes durations.
Higher levels were associated with higher HbA1c and, at longer durations, with higher albumin-creatinine ratio.
Adiponectin levels showed consistency within individuals that was not explained by these factors.
We conclude that markers for insulin resistance are associated with lower adiponectin, and markers for potential microvascular complications are associated with higher adiponectin.
The previously reported relationship with HbA1c remains largely unexplained.
Additional individual specific factors likely also influence adiponectin level.
The relationship between adiponectin and urinary protein excretion may enable identification of those predisposed to kidney disease earlier in type 1 diabetes.
American Psychological Association (APA)
LeCaire, Tamara J.& Palta, Mari. 2015. Longitudinal Analysis of Adiponectin through 20-Year Type 1 Diabetes Duration. Journal of Diabetes Research،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1067987
Modern Language Association (MLA)
LeCaire, Tamara J.& Palta, Mari. Longitudinal Analysis of Adiponectin through 20-Year Type 1 Diabetes Duration. Journal of Diabetes Research No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1067987
American Medical Association (AMA)
LeCaire, Tamara J.& Palta, Mari. Longitudinal Analysis of Adiponectin through 20-Year Type 1 Diabetes Duration. Journal of Diabetes Research. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1067987
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1067987