Moderate Intensity Training Impact on the Inflammatory Status and Glycemic Profiles in NOD Mice
المؤلفون المشاركون
Luzi, Livio
Codella, Roberto
Lanzoni, Giacomo
Zoso, Alessia
Caumo, Andrea
Montesano, Anna
Terruzzi, Ileana M.
Inverardi, Luca
Ricordi, Camillo
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-08-05
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
The nonobese diabetic (NOD) mouse represents a well-established experimental model analogous to human type 1 diabetes mellitus (T1D) as it is characterized by progressive autoimmune destruction of pancreatic β-cells.
Experiments were designed to investigate the impact of moderate-intensity training on T1D immunomodulation and inflammation.
Under a chronic exercise regime, NOD mice were trained on a treadmill for 12 weeks (12 m/min for 30 min, 5 d/wk) while age-matched, control animals were left untrained.
Prior to and upon completion of the training period, fed plasma glucose and immunological soluble factors were monitored.
Both groups showed deteriorated glycemic profiles throughout the study although trained mice tended to be more compensated than controls after 10 weeks of training.
An exercise-induced weight loss was detected in the trained mice with respect to the controls from week 6.
After 12 weeks, IL-6 and MIP-1β were decreased in the trained animals compared to their baseline values and versus controls, although not significantly.
Morphometric analysis of pancreata revealed the presence of larger infiltrates along with decreased α-cells areas in the control mice compared to trained mice.
Exercise may exert positive immunomodulation of systemic functions with respect to both T1D and inflammation, but only in a stringent therapeutic window.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Codella, Roberto& Lanzoni, Giacomo& Zoso, Alessia& Caumo, Andrea& Montesano, Anna& Terruzzi, Ileana M.…[et al.]. 2015. Moderate Intensity Training Impact on the Inflammatory Status and Glycemic Profiles in NOD Mice. Journal of Diabetes Research،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1067989
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Codella, Roberto…[et al.]. Moderate Intensity Training Impact on the Inflammatory Status and Glycemic Profiles in NOD Mice. Journal of Diabetes Research No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1067989
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Codella, Roberto& Lanzoni, Giacomo& Zoso, Alessia& Caumo, Andrea& Montesano, Anna& Terruzzi, Ileana M.…[et al.]. Moderate Intensity Training Impact on the Inflammatory Status and Glycemic Profiles in NOD Mice. Journal of Diabetes Research. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1067989
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1067989
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر