Moderate Intensity Training Impact on the Inflammatory Status and Glycemic Profiles in NOD Mice
Joint Authors
Luzi, Livio
Codella, Roberto
Lanzoni, Giacomo
Zoso, Alessia
Caumo, Andrea
Montesano, Anna
Terruzzi, Ileana M.
Inverardi, Luca
Ricordi, Camillo
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-05
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
The nonobese diabetic (NOD) mouse represents a well-established experimental model analogous to human type 1 diabetes mellitus (T1D) as it is characterized by progressive autoimmune destruction of pancreatic β-cells.
Experiments were designed to investigate the impact of moderate-intensity training on T1D immunomodulation and inflammation.
Under a chronic exercise regime, NOD mice were trained on a treadmill for 12 weeks (12 m/min for 30 min, 5 d/wk) while age-matched, control animals were left untrained.
Prior to and upon completion of the training period, fed plasma glucose and immunological soluble factors were monitored.
Both groups showed deteriorated glycemic profiles throughout the study although trained mice tended to be more compensated than controls after 10 weeks of training.
An exercise-induced weight loss was detected in the trained mice with respect to the controls from week 6.
After 12 weeks, IL-6 and MIP-1β were decreased in the trained animals compared to their baseline values and versus controls, although not significantly.
Morphometric analysis of pancreata revealed the presence of larger infiltrates along with decreased α-cells areas in the control mice compared to trained mice.
Exercise may exert positive immunomodulation of systemic functions with respect to both T1D and inflammation, but only in a stringent therapeutic window.
American Psychological Association (APA)
Codella, Roberto& Lanzoni, Giacomo& Zoso, Alessia& Caumo, Andrea& Montesano, Anna& Terruzzi, Ileana M.…[et al.]. 2015. Moderate Intensity Training Impact on the Inflammatory Status and Glycemic Profiles in NOD Mice. Journal of Diabetes Research،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1067989
Modern Language Association (MLA)
Codella, Roberto…[et al.]. Moderate Intensity Training Impact on the Inflammatory Status and Glycemic Profiles in NOD Mice. Journal of Diabetes Research No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1067989
American Medical Association (AMA)
Codella, Roberto& Lanzoni, Giacomo& Zoso, Alessia& Caumo, Andrea& Montesano, Anna& Terruzzi, Ileana M.…[et al.]. Moderate Intensity Training Impact on the Inflammatory Status and Glycemic Profiles in NOD Mice. Journal of Diabetes Research. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1067989
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1067989