MicroRNA-223 Expression Is Upregulated in Insulin Resistant Human Adipose Tissue
المؤلفون المشاركون
Chuang, Tung-Yueh
Wu, Hsiao-Li
Chen, Chen-Chun
Gamboa, Gloria Mabel
Layman, Lawrence C.
Diamond, Michael P.
Azziz, Ricardo
Chen, Yen-Hao
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-07-27
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
MicroRNAs (miRNAs) are short noncoding RNAs involved in posttranscriptional regulation of gene expression and influence many cellular functions including glucose and lipid metabolism.
We previously reported that adipose tissue (AT) from women with polycystic ovary syndrome (PCOS) or controls with insulin resistance (IR) revealed a differentially expressed microRNA (miRNA) profile, including upregulated miR-93 in PCOS patients and in non-PCOS women with IR.
Overexpressed miR-93 directly inhibited glucose transporter isoform 4 (GLUT4) expression, thereby influencing glucose metabolism.
We have now studied the role of miR-223, which is also abnormally expressed in the AT of IR subjects.
Our data indicates that miR-223 is significantly overexpressed in the AT of IR women, regardless of whether they had PCOS or not.
miR-223 expression in AT was positively correlated with HOMA-IR.
Unlike what is reported in cardiomyocytes, overexpression of miR-223 in human differentiated adipocytes was associated with a reduction in GLUT4 protein content and insulin-stimulated glucose uptake.
In addition, our data suggests miR-223 regulates GLUT4 expression by direct binding to its 3′ untranslated region (3′UTR).
In conclusion, in AT miR-223 is an IR-related miRNA that may serve as a potential therapeutic target for the treatment of IR-related disorders.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chuang, Tung-Yueh& Wu, Hsiao-Li& Chen, Chen-Chun& Gamboa, Gloria Mabel& Layman, Lawrence C.& Diamond, Michael P.…[et al.]. 2015. MicroRNA-223 Expression Is Upregulated in Insulin Resistant Human Adipose Tissue. Journal of Diabetes Research،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1068034
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chuang, Tung-Yueh…[et al.]. MicroRNA-223 Expression Is Upregulated in Insulin Resistant Human Adipose Tissue. Journal of Diabetes Research No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1068034
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chuang, Tung-Yueh& Wu, Hsiao-Li& Chen, Chen-Chun& Gamboa, Gloria Mabel& Layman, Lawrence C.& Diamond, Michael P.…[et al.]. MicroRNA-223 Expression Is Upregulated in Insulin Resistant Human Adipose Tissue. Journal of Diabetes Research. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1068034
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1068034
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر