MicroRNA-223 Expression Is Upregulated in Insulin Resistant Human Adipose Tissue
Joint Authors
Chuang, Tung-Yueh
Wu, Hsiao-Li
Chen, Chen-Chun
Gamboa, Gloria Mabel
Layman, Lawrence C.
Diamond, Michael P.
Azziz, Ricardo
Chen, Yen-Hao
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-07-27
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
MicroRNAs (miRNAs) are short noncoding RNAs involved in posttranscriptional regulation of gene expression and influence many cellular functions including glucose and lipid metabolism.
We previously reported that adipose tissue (AT) from women with polycystic ovary syndrome (PCOS) or controls with insulin resistance (IR) revealed a differentially expressed microRNA (miRNA) profile, including upregulated miR-93 in PCOS patients and in non-PCOS women with IR.
Overexpressed miR-93 directly inhibited glucose transporter isoform 4 (GLUT4) expression, thereby influencing glucose metabolism.
We have now studied the role of miR-223, which is also abnormally expressed in the AT of IR subjects.
Our data indicates that miR-223 is significantly overexpressed in the AT of IR women, regardless of whether they had PCOS or not.
miR-223 expression in AT was positively correlated with HOMA-IR.
Unlike what is reported in cardiomyocytes, overexpression of miR-223 in human differentiated adipocytes was associated with a reduction in GLUT4 protein content and insulin-stimulated glucose uptake.
In addition, our data suggests miR-223 regulates GLUT4 expression by direct binding to its 3′ untranslated region (3′UTR).
In conclusion, in AT miR-223 is an IR-related miRNA that may serve as a potential therapeutic target for the treatment of IR-related disorders.
American Psychological Association (APA)
Chuang, Tung-Yueh& Wu, Hsiao-Li& Chen, Chen-Chun& Gamboa, Gloria Mabel& Layman, Lawrence C.& Diamond, Michael P.…[et al.]. 2015. MicroRNA-223 Expression Is Upregulated in Insulin Resistant Human Adipose Tissue. Journal of Diabetes Research،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1068034
Modern Language Association (MLA)
Chuang, Tung-Yueh…[et al.]. MicroRNA-223 Expression Is Upregulated in Insulin Resistant Human Adipose Tissue. Journal of Diabetes Research No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1068034
American Medical Association (AMA)
Chuang, Tung-Yueh& Wu, Hsiao-Li& Chen, Chen-Chun& Gamboa, Gloria Mabel& Layman, Lawrence C.& Diamond, Michael P.…[et al.]. MicroRNA-223 Expression Is Upregulated in Insulin Resistant Human Adipose Tissue. Journal of Diabetes Research. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1068034
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1068034