Immunotherapy of Ovarian Cancer: The Role of Checkpoint Inhibitors
المؤلفون المشاركون
Marchetti, Claudia
Palaia, Innocenza
Muzii, Ludovico
Tombolini, Vincenzo
De Felice, Francesca
Musio, Daniela
Panici, Pierluigi Benedetti
المصدر
Journal of Immunology Research
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-07-07
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Ovarian cancer is the most important cause of gynecological cancer-related mortality, with the majority of women presenting with advanced disease.
Although surgery and chemotherapy can improve survival rates, it is necessary to integrate alternative strategies to improve the outcomes.
Advances in understanding the role of immune system in the pathogenesis of cancer have led to the rapid evolvement of immunotherapy, which might establish a sustained immune system response against recurring cancer cells.
Recently, it has emerged that powerful immunologic effector cells may be blocked by inhibitory regulatory pathways controlled by specific molecules often called “immune checkpoints,” which turn off the immune system.
Similarly, cancer cells are able to use these checkpoints to avoid immune control and rejection.
Inhibition of these inhibitory pathways represents a potent strategy in the fight against cancer and is currently under investigation with encouraging results in some cancers, such as melanoma.
In ovarian cancer researches are still in an early phase, but with promising results.
In this review we will explore the rationale of immunotherapy in ovarian cancer with a special focus on these emerging molecules.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
De Felice, Francesca& Marchetti, Claudia& Palaia, Innocenza& Musio, Daniela& Muzii, Ludovico& Tombolini, Vincenzo…[et al.]. 2015. Immunotherapy of Ovarian Cancer: The Role of Checkpoint Inhibitors. Journal of Immunology Research،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1068396
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
De Felice, Francesca…[et al.]. Immunotherapy of Ovarian Cancer: The Role of Checkpoint Inhibitors. Journal of Immunology Research No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1068396
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
De Felice, Francesca& Marchetti, Claudia& Palaia, Innocenza& Musio, Daniela& Muzii, Ludovico& Tombolini, Vincenzo…[et al.]. Immunotherapy of Ovarian Cancer: The Role of Checkpoint Inhibitors. Journal of Immunology Research. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1068396
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1068396
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر