Immunotherapy of Ovarian Cancer: The Role of Checkpoint Inhibitors
Joint Authors
Marchetti, Claudia
Palaia, Innocenza
Muzii, Ludovico
Tombolini, Vincenzo
De Felice, Francesca
Musio, Daniela
Panici, Pierluigi Benedetti
Source
Journal of Immunology Research
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-07-07
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Ovarian cancer is the most important cause of gynecological cancer-related mortality, with the majority of women presenting with advanced disease.
Although surgery and chemotherapy can improve survival rates, it is necessary to integrate alternative strategies to improve the outcomes.
Advances in understanding the role of immune system in the pathogenesis of cancer have led to the rapid evolvement of immunotherapy, which might establish a sustained immune system response against recurring cancer cells.
Recently, it has emerged that powerful immunologic effector cells may be blocked by inhibitory regulatory pathways controlled by specific molecules often called “immune checkpoints,” which turn off the immune system.
Similarly, cancer cells are able to use these checkpoints to avoid immune control and rejection.
Inhibition of these inhibitory pathways represents a potent strategy in the fight against cancer and is currently under investigation with encouraging results in some cancers, such as melanoma.
In ovarian cancer researches are still in an early phase, but with promising results.
In this review we will explore the rationale of immunotherapy in ovarian cancer with a special focus on these emerging molecules.
American Psychological Association (APA)
De Felice, Francesca& Marchetti, Claudia& Palaia, Innocenza& Musio, Daniela& Muzii, Ludovico& Tombolini, Vincenzo…[et al.]. 2015. Immunotherapy of Ovarian Cancer: The Role of Checkpoint Inhibitors. Journal of Immunology Research،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1068396
Modern Language Association (MLA)
De Felice, Francesca…[et al.]. Immunotherapy of Ovarian Cancer: The Role of Checkpoint Inhibitors. Journal of Immunology Research No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1068396
American Medical Association (AMA)
De Felice, Francesca& Marchetti, Claudia& Palaia, Innocenza& Musio, Daniela& Muzii, Ludovico& Tombolini, Vincenzo…[et al.]. Immunotherapy of Ovarian Cancer: The Role of Checkpoint Inhibitors. Journal of Immunology Research. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1068396
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1068396