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Significance of Circulating and Crevicular Matrix Metalloproteinase-9 in Rheumatoid Arthritis-Chronic Periodontitis Association
المؤلفون المشاركون
Surlin, Petra
Silosi, Isabela
Silosi, Isabela
Cojocaru, Manole
Foia, Lili
Petrescu, Florin
Biciusca, Viorel
المصدر
Journal of Immunology Research
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-03-03
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
In the recent years, statistically significant associations between rheumatoid arthritis (RA) andperiodontal disease have been identified.
Emerging as a chronic inflammatory joint disease, RA displays various features and pathogenetic events similar to chronic periodontitis (CP).
The purpose of this study was to evaluate the utility of determining systemic and crevicular levels of metalloproteinase-9 (MMP-9) as potential biomarkers for association between RA and CP.
A total of fifty-six patients were included in the study.
The subjects were categorized into four groups as follows: healthy-control ( n = 21 ), active RA ( n = 16 ), CP ( n = 14 ), and RA-CP association ( n = 12 ).
Assessment of serum and crevicular concentrations of total MMP-9 (active and pro-MMP-9) was based on ELISA technique.
The results of this study showed statistically significant differences of serum MMP-9 between patients groups and control.
Serum levels of MMP-9 were similar in RA and RA-CP associated patients.
Gingival crevicular fluid (GCF) recorded increased MMP-9 levels in RA-CP association subjects as compared to CP.
Considering that RA-CP association is characterized by a disregulation of the inflammatory response, MMP-9 may play a role in the pathogenesis of RA-CP association.
MMP-9 is therefore a sensitive tool in the diagnosis and management of patients affected by this binomial association.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Silosi, Isabela& Cojocaru, Manole& Foia, Lili& Silosi, Isabela& Petrescu, Florin& Surlin, Petra…[et al.]. 2015. Significance of Circulating and Crevicular Matrix Metalloproteinase-9 in Rheumatoid Arthritis-Chronic Periodontitis Association. Journal of Immunology Research،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1068410
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Silosi, Isabela…[et al.]. Significance of Circulating and Crevicular Matrix Metalloproteinase-9 in Rheumatoid Arthritis-Chronic Periodontitis Association. Journal of Immunology Research No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1068410
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Silosi, Isabela& Cojocaru, Manole& Foia, Lili& Silosi, Isabela& Petrescu, Florin& Surlin, Petra…[et al.]. Significance of Circulating and Crevicular Matrix Metalloproteinase-9 in Rheumatoid Arthritis-Chronic Periodontitis Association. Journal of Immunology Research. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1068410
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1068410
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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