Significance of Circulating and Crevicular Matrix Metalloproteinase-9 in Rheumatoid Arthritis-Chronic Periodontitis Association
Joint Authors
Surlin, Petra
Silosi, Isabela
Silosi, Isabela
Cojocaru, Manole
Foia, Lili
Petrescu, Florin
Biciusca, Viorel
Source
Journal of Immunology Research
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-03
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
In the recent years, statistically significant associations between rheumatoid arthritis (RA) andperiodontal disease have been identified.
Emerging as a chronic inflammatory joint disease, RA displays various features and pathogenetic events similar to chronic periodontitis (CP).
The purpose of this study was to evaluate the utility of determining systemic and crevicular levels of metalloproteinase-9 (MMP-9) as potential biomarkers for association between RA and CP.
A total of fifty-six patients were included in the study.
The subjects were categorized into four groups as follows: healthy-control ( n = 21 ), active RA ( n = 16 ), CP ( n = 14 ), and RA-CP association ( n = 12 ).
Assessment of serum and crevicular concentrations of total MMP-9 (active and pro-MMP-9) was based on ELISA technique.
The results of this study showed statistically significant differences of serum MMP-9 between patients groups and control.
Serum levels of MMP-9 were similar in RA and RA-CP associated patients.
Gingival crevicular fluid (GCF) recorded increased MMP-9 levels in RA-CP association subjects as compared to CP.
Considering that RA-CP association is characterized by a disregulation of the inflammatory response, MMP-9 may play a role in the pathogenesis of RA-CP association.
MMP-9 is therefore a sensitive tool in the diagnosis and management of patients affected by this binomial association.
American Psychological Association (APA)
Silosi, Isabela& Cojocaru, Manole& Foia, Lili& Silosi, Isabela& Petrescu, Florin& Surlin, Petra…[et al.]. 2015. Significance of Circulating and Crevicular Matrix Metalloproteinase-9 in Rheumatoid Arthritis-Chronic Periodontitis Association. Journal of Immunology Research،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1068410
Modern Language Association (MLA)
Silosi, Isabela…[et al.]. Significance of Circulating and Crevicular Matrix Metalloproteinase-9 in Rheumatoid Arthritis-Chronic Periodontitis Association. Journal of Immunology Research No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1068410
American Medical Association (AMA)
Silosi, Isabela& Cojocaru, Manole& Foia, Lili& Silosi, Isabela& Petrescu, Florin& Surlin, Petra…[et al.]. Significance of Circulating and Crevicular Matrix Metalloproteinase-9 in Rheumatoid Arthritis-Chronic Periodontitis Association. Journal of Immunology Research. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1068410
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1068410