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The Expansion of CD25highIL-10highFoxP3high B Regulatory Cells Is in Association with SLE Disease Activity
المؤلفون المشاركون
Vadasz, Zahava
Peri, Regina
Eiza, Nasren
Slobodin, Gleb
Balbir-Gurman, Alexandra
Toubi, Elias
المصدر
Journal of Immunology Research
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-10-04
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
B regulatory cells (Bregs) belong to a subgroup of activated B cells tasked with maintaining self-tolerance and preventing autoimmunity.
While sharing similar regulatory mechanisms such as IL-10 dependency, they also defer in exhibiting their suppressive effects by expressing Fas-Ligand, TGF-beta, and PDL-1.
In this study we show, for the first time, the expansion of CD25highFoxP3high Bregs in systemic lupus erythematosus (SLE) patients compared to healthy individuals (18.5 ± 3.052% versus 11.0 ± 1.654%, p<0.001, resp.).
This expansion was also shown to correlate with SLE disease activity (r=0.75).
In addition, CD25highFoxP3high Bregs were also IL-10high expressing and further expanded when stimulated with semaphorin 3A.
In sum we show that CD25highFoxP3high are an additional subtype of Bregs, involved in regulating SLE disease activity.
Being IL-10 expressing, we may assume that they are one of the sources of increased serum IL-10 in SLE patients.
Further studies are required in order to assess the relation between high serum IL-10 and CD25highFoxP3high Breg cells.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Vadasz, Zahava& Peri, Regina& Eiza, Nasren& Slobodin, Gleb& Balbir-Gurman, Alexandra& Toubi, Elias. 2015. The Expansion of CD25highIL-10highFoxP3high B Regulatory Cells Is in Association with SLE Disease Activity. Journal of Immunology Research،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1068420
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Vadasz, Zahava…[et al.]. The Expansion of CD25highIL-10highFoxP3high B Regulatory Cells Is in Association with SLE Disease Activity. Journal of Immunology Research No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1068420
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Vadasz, Zahava& Peri, Regina& Eiza, Nasren& Slobodin, Gleb& Balbir-Gurman, Alexandra& Toubi, Elias. The Expansion of CD25highIL-10highFoxP3high B Regulatory Cells Is in Association with SLE Disease Activity. Journal of Immunology Research. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1068420
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1068420
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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