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The Expansion of CD25highIL-10highFoxP3high B Regulatory Cells Is in Association with SLE Disease Activity
Joint Authors
Vadasz, Zahava
Peri, Regina
Eiza, Nasren
Slobodin, Gleb
Balbir-Gurman, Alexandra
Toubi, Elias
Source
Journal of Immunology Research
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-04
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
B regulatory cells (Bregs) belong to a subgroup of activated B cells tasked with maintaining self-tolerance and preventing autoimmunity.
While sharing similar regulatory mechanisms such as IL-10 dependency, they also defer in exhibiting their suppressive effects by expressing Fas-Ligand, TGF-beta, and PDL-1.
In this study we show, for the first time, the expansion of CD25highFoxP3high Bregs in systemic lupus erythematosus (SLE) patients compared to healthy individuals (18.5 ± 3.052% versus 11.0 ± 1.654%, p<0.001, resp.).
This expansion was also shown to correlate with SLE disease activity (r=0.75).
In addition, CD25highFoxP3high Bregs were also IL-10high expressing and further expanded when stimulated with semaphorin 3A.
In sum we show that CD25highFoxP3high are an additional subtype of Bregs, involved in regulating SLE disease activity.
Being IL-10 expressing, we may assume that they are one of the sources of increased serum IL-10 in SLE patients.
Further studies are required in order to assess the relation between high serum IL-10 and CD25highFoxP3high Breg cells.
American Psychological Association (APA)
Vadasz, Zahava& Peri, Regina& Eiza, Nasren& Slobodin, Gleb& Balbir-Gurman, Alexandra& Toubi, Elias. 2015. The Expansion of CD25highIL-10highFoxP3high B Regulatory Cells Is in Association with SLE Disease Activity. Journal of Immunology Research،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1068420
Modern Language Association (MLA)
Vadasz, Zahava…[et al.]. The Expansion of CD25highIL-10highFoxP3high B Regulatory Cells Is in Association with SLE Disease Activity. Journal of Immunology Research No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1068420
American Medical Association (AMA)
Vadasz, Zahava& Peri, Regina& Eiza, Nasren& Slobodin, Gleb& Balbir-Gurman, Alexandra& Toubi, Elias. The Expansion of CD25highIL-10highFoxP3high B Regulatory Cells Is in Association with SLE Disease Activity. Journal of Immunology Research. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1068420
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1068420