Effective Binding of a Phosphatidylserine-Targeting Antibody to Ebola Virus Infected Cells and Purified Virions

الملخص EN

Ebola virus is responsible for causing severe hemorrhagic fevers, with case fatality rates of up to 90%.

Currently, no antiviral or vaccine is licensed against Ebola virus.

A phosphatidylserine-targeting antibody (PGN401, bavituximab) has previously been shown to have broad-spectrum antiviral activity.

Here, we demonstrate that PGN401 specifically binds to Ebola virus and recognizes infected cells.

Our study provides the first evidence of phosphatidylserine-targeting antibody reactivity against Ebola virus.