Effective Binding of a Phosphatidylserine-Targeting Antibody to Ebola Virus Infected Cells and Purified Virions
Joint Authors
Graham, V. A.
Dowall, S. D.
Corbin-Lickfett, K.
Empig, C.
Schlunegger, K.
Bruce, C. B.
Easterbrook, L.
Hewson, R.
Source
Journal of Immunology Research
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-01
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Ebola virus is responsible for causing severe hemorrhagic fevers, with case fatality rates of up to 90%.
Currently, no antiviral or vaccine is licensed against Ebola virus.
A phosphatidylserine-targeting antibody (PGN401, bavituximab) has previously been shown to have broad-spectrum antiviral activity.
Here, we demonstrate that PGN401 specifically binds to Ebola virus and recognizes infected cells.
Our study provides the first evidence of phosphatidylserine-targeting antibody reactivity against Ebola virus.
American Psychological Association (APA)
Dowall, S. D.& Graham, V. A.& Corbin-Lickfett, K.& Empig, C.& Schlunegger, K.& Bruce, C. B.…[et al.]. 2015. Effective Binding of a Phosphatidylserine-Targeting Antibody to Ebola Virus Infected Cells and Purified Virions. Journal of Immunology Research،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1068445
Modern Language Association (MLA)
Dowall, S. D.…[et al.]. Effective Binding of a Phosphatidylserine-Targeting Antibody to Ebola Virus Infected Cells and Purified Virions. Journal of Immunology Research No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1068445
American Medical Association (AMA)
Dowall, S. D.& Graham, V. A.& Corbin-Lickfett, K.& Empig, C.& Schlunegger, K.& Bruce, C. B.…[et al.]. Effective Binding of a Phosphatidylserine-Targeting Antibody to Ebola Virus Infected Cells and Purified Virions. Journal of Immunology Research. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1068445
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1068445
