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Age-Related Differences in Percentages of Regulatory and Effector T Lymphocytes and Their Subsets in Healthy Individuals and Characteristic STAT1STAT5 Signalling Response in Helper T Lymphocytes
المؤلفون المشاركون
Ihan, Alojz
Holcar, Marija
Goropevšek, Aleš
Avčin, Tadej
المصدر
Journal of Immunology Research
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-10-07
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
The dynamic process of the development of the immune system can in itself result in age-related immune malfunctions.
In this study, we analysed lymphocyte subsets in the peripheral blood of 60 healthy donors, divided into groups of children, adolescents, and adults, focusing on effector (Teff) and regulatory (Treg) T lymphocytes and STAT1/STAT5 signalling response in helper T lymphocytes (Th) in adults, using flow cytometry.
Our results demonstrate a decrease in the percentage of total Tregs and an increase in the percentage of total Teffs with age and a consequential immense increase in the Teff/Treg ratio.
The increase of Teffs was most apparent in Th1, Th1Th17, and Th17CD161− subsets.
Significant Th lymphocyte STAT1 expression differences were observed between children and adolescents, which were associated with the decrease in activated Tregs.
Higher expression of STAT1 was found in FoxP3hi than in FoxP3low Th lymphocytes, while significant IL-2 induced STAT5 phosphorylation differences were found among the subsets of Th lymphocytes in adults.
Our study demonstrates age-related changes in circulating Teff and Treg, as well as significant differences in STAT5/STAT1 signalling among FoxP3+ Th lymphocytes, providing new advances in the understanding of immunosenescence.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Holcar, Marija& Goropevšek, Aleš& Ihan, Alojz& Avčin, Tadej. 2015. Age-Related Differences in Percentages of Regulatory and Effector T Lymphocytes and Their Subsets in Healthy Individuals and Characteristic STAT1STAT5 Signalling Response in Helper T Lymphocytes. Journal of Immunology Research،Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1068450
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Holcar, Marija…[et al.]. Age-Related Differences in Percentages of Regulatory and Effector T Lymphocytes and Their Subsets in Healthy Individuals and Characteristic STAT1STAT5 Signalling Response in Helper T Lymphocytes. Journal of Immunology Research No. 2015 (2015), pp.1-13.
https://search.emarefa.net/detail/BIM-1068450
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Holcar, Marija& Goropevšek, Aleš& Ihan, Alojz& Avčin, Tadej. Age-Related Differences in Percentages of Regulatory and Effector T Lymphocytes and Their Subsets in Healthy Individuals and Characteristic STAT1STAT5 Signalling Response in Helper T Lymphocytes. Journal of Immunology Research. 2015. Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1068450
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1068450
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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