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Age-Related Differences in Percentages of Regulatory and Effector T Lymphocytes and Their Subsets in Healthy Individuals and Characteristic STAT1STAT5 Signalling Response in Helper T Lymphocytes
Joint Authors
Ihan, Alojz
Holcar, Marija
Goropevšek, Aleš
Avčin, Tadej
Source
Journal of Immunology Research
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-07
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
The dynamic process of the development of the immune system can in itself result in age-related immune malfunctions.
In this study, we analysed lymphocyte subsets in the peripheral blood of 60 healthy donors, divided into groups of children, adolescents, and adults, focusing on effector (Teff) and regulatory (Treg) T lymphocytes and STAT1/STAT5 signalling response in helper T lymphocytes (Th) in adults, using flow cytometry.
Our results demonstrate a decrease in the percentage of total Tregs and an increase in the percentage of total Teffs with age and a consequential immense increase in the Teff/Treg ratio.
The increase of Teffs was most apparent in Th1, Th1Th17, and Th17CD161− subsets.
Significant Th lymphocyte STAT1 expression differences were observed between children and adolescents, which were associated with the decrease in activated Tregs.
Higher expression of STAT1 was found in FoxP3hi than in FoxP3low Th lymphocytes, while significant IL-2 induced STAT5 phosphorylation differences were found among the subsets of Th lymphocytes in adults.
Our study demonstrates age-related changes in circulating Teff and Treg, as well as significant differences in STAT5/STAT1 signalling among FoxP3+ Th lymphocytes, providing new advances in the understanding of immunosenescence.
American Psychological Association (APA)
Holcar, Marija& Goropevšek, Aleš& Ihan, Alojz& Avčin, Tadej. 2015. Age-Related Differences in Percentages of Regulatory and Effector T Lymphocytes and Their Subsets in Healthy Individuals and Characteristic STAT1STAT5 Signalling Response in Helper T Lymphocytes. Journal of Immunology Research،Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1068450
Modern Language Association (MLA)
Holcar, Marija…[et al.]. Age-Related Differences in Percentages of Regulatory and Effector T Lymphocytes and Their Subsets in Healthy Individuals and Characteristic STAT1STAT5 Signalling Response in Helper T Lymphocytes. Journal of Immunology Research No. 2015 (2015), pp.1-13.
https://search.emarefa.net/detail/BIM-1068450
American Medical Association (AMA)
Holcar, Marija& Goropevšek, Aleš& Ihan, Alojz& Avčin, Tadej. Age-Related Differences in Percentages of Regulatory and Effector T Lymphocytes and Their Subsets in Healthy Individuals and Characteristic STAT1STAT5 Signalling Response in Helper T Lymphocytes. Journal of Immunology Research. 2015. Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1068450
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1068450