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How the Intricate Interaction among Toll-Like Receptors, Microbiota, and Intestinal Immunity Can Influence Gastrointestinal Pathology
المؤلفون المشاركون
Cianci, Rossella
Cianci, R.
Frosali, S.
Gambassi, Giovanni
Landolfi, R.
Pandolfi, Franco
المصدر
Journal of Immunology Research
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-05-18
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
The gut is able to maintain tolerance to microbial and food antigens.
The intestine minimizes the number of harmful bacteria by shaping the microbiota through a symbiotic relationship.
In healthy human intestine, a constant homeostasis is maintained by the perfect regulation of microbial load and the immune response generated against it.
Failure of this balance may result in various pathological conditions.
Innate immune sensors, such as Toll-like receptors (TLRs), may be considered an interface among intestinal epithelial barrier, microbiota, and immune system.
TLRs pathway, activated by pathogens, is involved in the pathogenesis of several infectious and inflammatory diseases.
The alteration of the homeostasis between physiologic and pathogenic bacteria of intestinal flora causes a condition called dysbiosis.
The breakdown of homeostasis by dysbiosis may increase susceptibility to inflammatory bowel diseases.
It is evident that environment, genetics, and host immunity form a highly interactive regulatory triad that controls TLR function.
Imbalanced relationships within this triad may promote aberrant TLR signaling, critically contributing to acute and chronic intestinal inflammatory processes, such as in IBD, colitis, and colorectal cancer.
The study of interactions between different components of the immune systems and intestinal microbiota will open new horizons in the knowledge of gut inflammation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Frosali, S.& Cianci, Rossella& Gambassi, Giovanni& Landolfi, R.& Pandolfi, Franco& Cianci, R.. 2015. How the Intricate Interaction among Toll-Like Receptors, Microbiota, and Intestinal Immunity Can Influence Gastrointestinal Pathology. Journal of Immunology Research،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1068495
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Frosali, S.…[et al.]. How the Intricate Interaction among Toll-Like Receptors, Microbiota, and Intestinal Immunity Can Influence Gastrointestinal Pathology. Journal of Immunology Research No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1068495
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Frosali, S.& Cianci, Rossella& Gambassi, Giovanni& Landolfi, R.& Pandolfi, Franco& Cianci, R.. How the Intricate Interaction among Toll-Like Receptors, Microbiota, and Intestinal Immunity Can Influence Gastrointestinal Pathology. Journal of Immunology Research. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1068495
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1068495
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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