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How the Intricate Interaction among Toll-Like Receptors, Microbiota, and Intestinal Immunity Can Influence Gastrointestinal Pathology
Joint Authors
Cianci, Rossella
Cianci, R.
Frosali, S.
Gambassi, Giovanni
Landolfi, R.
Pandolfi, Franco
Source
Journal of Immunology Research
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-18
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The gut is able to maintain tolerance to microbial and food antigens.
The intestine minimizes the number of harmful bacteria by shaping the microbiota through a symbiotic relationship.
In healthy human intestine, a constant homeostasis is maintained by the perfect regulation of microbial load and the immune response generated against it.
Failure of this balance may result in various pathological conditions.
Innate immune sensors, such as Toll-like receptors (TLRs), may be considered an interface among intestinal epithelial barrier, microbiota, and immune system.
TLRs pathway, activated by pathogens, is involved in the pathogenesis of several infectious and inflammatory diseases.
The alteration of the homeostasis between physiologic and pathogenic bacteria of intestinal flora causes a condition called dysbiosis.
The breakdown of homeostasis by dysbiosis may increase susceptibility to inflammatory bowel diseases.
It is evident that environment, genetics, and host immunity form a highly interactive regulatory triad that controls TLR function.
Imbalanced relationships within this triad may promote aberrant TLR signaling, critically contributing to acute and chronic intestinal inflammatory processes, such as in IBD, colitis, and colorectal cancer.
The study of interactions between different components of the immune systems and intestinal microbiota will open new horizons in the knowledge of gut inflammation.
American Psychological Association (APA)
Frosali, S.& Cianci, Rossella& Gambassi, Giovanni& Landolfi, R.& Pandolfi, Franco& Cianci, R.. 2015. How the Intricate Interaction among Toll-Like Receptors, Microbiota, and Intestinal Immunity Can Influence Gastrointestinal Pathology. Journal of Immunology Research،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1068495
Modern Language Association (MLA)
Frosali, S.…[et al.]. How the Intricate Interaction among Toll-Like Receptors, Microbiota, and Intestinal Immunity Can Influence Gastrointestinal Pathology. Journal of Immunology Research No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1068495
American Medical Association (AMA)
Frosali, S.& Cianci, Rossella& Gambassi, Giovanni& Landolfi, R.& Pandolfi, Franco& Cianci, R.. How the Intricate Interaction among Toll-Like Receptors, Microbiota, and Intestinal Immunity Can Influence Gastrointestinal Pathology. Journal of Immunology Research. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1068495
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1068495