Decreased Frequency of Circulating Myelin Oligodendrocyte Glycoprotein B Lymphocytes in Patients with Relapsing-Remitting Multiple Sclerosis
المؤلفون المشاركون
Elong Ngono, Annie
Lepetit, Maud
Reindl, Markus
Garcia, Alexandra
Guillot, Flora
Genty, Athénaïs
Chesneau, Mélanie
Salou, Marion
Michel, Laure
Lefrere, Fabienne
Schanda, Kathrin
Imbert-Marcille, Berthe-Marie
Degauque, Nicolas
Nicot, Arnaud
Brouard, Sophie
Laplaud, David-Axel
Soulillou, Jean-Paul
المصدر
Journal of Immunology Research
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-05-18
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Although there is no evidence for a role of anti-MOG antibodies in adult MS, no information on B lymphocytes with MOG-committed BCR is available.
We report here on the frequency of anti-MOG B cells forming rosettes with polystyrene beads (BBR) covalently bound to the extracellular domain of rhMOG in 38 relapsing-remitting patients (RRMS) and 50 healthy individuals (HI).
We show a substantial proportion of circulating anti-MOG-BBR in both RRMS and HI.
Strikingly, MOG-specific B cells frequencies were lower in MS than in HI.
Anti-MOG antibodies measured by a cell-based assay were not different between MS patients and controls, suggesting a specific alteration of anti-MOG B cells in MS.
Although anti-MOG-BBR were higher in CNS fluid than in blood, no difference was observed between MS and controls.
Lower frequency of MOG-BBR in MS was not explained by an increased apoptosis, but a trend for lower proliferative capacity was noted.
Despite an efficient B cell transmigration across brain derived endothelial cells, total and anti-MOG B cells transmigration was similar between MS and HI.
The striking alteration in MOG-specific B cells, independent of anti-MOG antibody titers, challenges our view on the role of MOG-specific B cells in MS.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Elong Ngono, Annie& Lepetit, Maud& Reindl, Markus& Garcia, Alexandra& Guillot, Flora& Genty, Athénaïs…[et al.]. 2015. Decreased Frequency of Circulating Myelin Oligodendrocyte Glycoprotein B Lymphocytes in Patients with Relapsing-Remitting Multiple Sclerosis. Journal of Immunology Research،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1068545
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Elong Ngono, Annie…[et al.]. Decreased Frequency of Circulating Myelin Oligodendrocyte Glycoprotein B Lymphocytes in Patients with Relapsing-Remitting Multiple Sclerosis. Journal of Immunology Research No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1068545
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Elong Ngono, Annie& Lepetit, Maud& Reindl, Markus& Garcia, Alexandra& Guillot, Flora& Genty, Athénaïs…[et al.]. Decreased Frequency of Circulating Myelin Oligodendrocyte Glycoprotein B Lymphocytes in Patients with Relapsing-Remitting Multiple Sclerosis. Journal of Immunology Research. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1068545
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1068545
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر