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Decreased Frequency of Circulating Myelin Oligodendrocyte Glycoprotein B Lymphocytes in Patients with Relapsing-Remitting Multiple Sclerosis
المؤلفون المشاركون
Elong Ngono, Annie
Lepetit, Maud
Reindl, Markus
Garcia, Alexandra
Guillot, Flora
Genty, Athénaïs
Chesneau, Mélanie
Salou, Marion
Michel, Laure
Lefrere, Fabienne
Schanda, Kathrin
Imbert-Marcille, Berthe-Marie
Degauque, Nicolas
Nicot, Arnaud
Brouard, Sophie
Laplaud, David-Axel
Soulillou, Jean-Paul
المصدر
Journal of Immunology Research
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-05-18
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Although there is no evidence for a role of anti-MOG antibodies in adult MS, no information on B lymphocytes with MOG-committed BCR is available.
We report here on the frequency of anti-MOG B cells forming rosettes with polystyrene beads (BBR) covalently bound to the extracellular domain of rhMOG in 38 relapsing-remitting patients (RRMS) and 50 healthy individuals (HI).
We show a substantial proportion of circulating anti-MOG-BBR in both RRMS and HI.
Strikingly, MOG-specific B cells frequencies were lower in MS than in HI.
Anti-MOG antibodies measured by a cell-based assay were not different between MS patients and controls, suggesting a specific alteration of anti-MOG B cells in MS.
Although anti-MOG-BBR were higher in CNS fluid than in blood, no difference was observed between MS and controls.
Lower frequency of MOG-BBR in MS was not explained by an increased apoptosis, but a trend for lower proliferative capacity was noted.
Despite an efficient B cell transmigration across brain derived endothelial cells, total and anti-MOG B cells transmigration was similar between MS and HI.
The striking alteration in MOG-specific B cells, independent of anti-MOG antibody titers, challenges our view on the role of MOG-specific B cells in MS.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Elong Ngono, Annie& Lepetit, Maud& Reindl, Markus& Garcia, Alexandra& Guillot, Flora& Genty, Athénaïs…[et al.]. 2015. Decreased Frequency of Circulating Myelin Oligodendrocyte Glycoprotein B Lymphocytes in Patients with Relapsing-Remitting Multiple Sclerosis. Journal of Immunology Research،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1068545
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Elong Ngono, Annie…[et al.]. Decreased Frequency of Circulating Myelin Oligodendrocyte Glycoprotein B Lymphocytes in Patients with Relapsing-Remitting Multiple Sclerosis. Journal of Immunology Research No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1068545
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Elong Ngono, Annie& Lepetit, Maud& Reindl, Markus& Garcia, Alexandra& Guillot, Flora& Genty, Athénaïs…[et al.]. Decreased Frequency of Circulating Myelin Oligodendrocyte Glycoprotein B Lymphocytes in Patients with Relapsing-Remitting Multiple Sclerosis. Journal of Immunology Research. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1068545
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1068545
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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