Decreased Frequency of Circulating Myelin Oligodendrocyte Glycoprotein B Lymphocytes in Patients with Relapsing-Remitting Multiple Sclerosis
Joint Authors
Elong Ngono, Annie
Lepetit, Maud
Reindl, Markus
Garcia, Alexandra
Guillot, Flora
Genty, Athénaïs
Chesneau, Mélanie
Salou, Marion
Michel, Laure
Lefrere, Fabienne
Schanda, Kathrin
Imbert-Marcille, Berthe-Marie
Degauque, Nicolas
Nicot, Arnaud
Brouard, Sophie
Laplaud, David-Axel
Soulillou, Jean-Paul
Source
Journal of Immunology Research
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-18
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Although there is no evidence for a role of anti-MOG antibodies in adult MS, no information on B lymphocytes with MOG-committed BCR is available.
We report here on the frequency of anti-MOG B cells forming rosettes with polystyrene beads (BBR) covalently bound to the extracellular domain of rhMOG in 38 relapsing-remitting patients (RRMS) and 50 healthy individuals (HI).
We show a substantial proportion of circulating anti-MOG-BBR in both RRMS and HI.
Strikingly, MOG-specific B cells frequencies were lower in MS than in HI.
Anti-MOG antibodies measured by a cell-based assay were not different between MS patients and controls, suggesting a specific alteration of anti-MOG B cells in MS.
Although anti-MOG-BBR were higher in CNS fluid than in blood, no difference was observed between MS and controls.
Lower frequency of MOG-BBR in MS was not explained by an increased apoptosis, but a trend for lower proliferative capacity was noted.
Despite an efficient B cell transmigration across brain derived endothelial cells, total and anti-MOG B cells transmigration was similar between MS and HI.
The striking alteration in MOG-specific B cells, independent of anti-MOG antibody titers, challenges our view on the role of MOG-specific B cells in MS.
American Psychological Association (APA)
Elong Ngono, Annie& Lepetit, Maud& Reindl, Markus& Garcia, Alexandra& Guillot, Flora& Genty, Athénaïs…[et al.]. 2015. Decreased Frequency of Circulating Myelin Oligodendrocyte Glycoprotein B Lymphocytes in Patients with Relapsing-Remitting Multiple Sclerosis. Journal of Immunology Research،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1068545
Modern Language Association (MLA)
Elong Ngono, Annie…[et al.]. Decreased Frequency of Circulating Myelin Oligodendrocyte Glycoprotein B Lymphocytes in Patients with Relapsing-Remitting Multiple Sclerosis. Journal of Immunology Research No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1068545
American Medical Association (AMA)
Elong Ngono, Annie& Lepetit, Maud& Reindl, Markus& Garcia, Alexandra& Guillot, Flora& Genty, Athénaïs…[et al.]. Decreased Frequency of Circulating Myelin Oligodendrocyte Glycoprotein B Lymphocytes in Patients with Relapsing-Remitting Multiple Sclerosis. Journal of Immunology Research. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1068545
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1068545