Achalasia—An Autoimmune Inflammatory Disease: A Cross-Sectional Study

المؤلفون المشاركون

Valdovinos, Miguel A.
Aguilar-León, D.
Gamboa-Domínguez, A.
Martín-del-Campo, L. A.
Enríquez, A. B.
Coss-Adame, E.
Svarch, A. E.
Flores-Nájera, A.
Villa-Baños, A.
Ceballos, J. C.
Nuñez-Álvarez, Carlos
Torres-Villalobos, Gonzalo
Furuzawa-Carballeda, Janette

المصدر

Journal of Immunology Research

العدد

المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-18، 18ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2015-05-20

دولة النشر

مصر

عدد الصفحات

18

التخصصات الرئيسية

الأحياء

الملخص EN

Idiopathic achalasia is a disease of unknown etiology.

The loss of myenteric plexus associated with inflammatory infiltrates and autoantibodies support the hypothesis of an autoimmune mechanism.

Thirty-two patients diagnosed by high-resolution manometry with achalasia were included.

Twenty-six specimens from lower esophageal sphincter muscle were compared with 5 esophagectomy biopsies (control).

Immunohistochemical (biopsies) and flow cytometry (peripheral blood) analyses were performed.

Circulating anti-myenteric autoantibodies were evaluated by indirect immunofluorescence.

Herpes simplex virus-1 (HSV-1) infection was determined by in situ hybridization, RT-PCR, and immunohistochemistry.

Histopathological analysis showed capillaritis (51%), plexitis (23%), nerve hypertrophy (16%), venulitis (7%), and fibrosis (3%).

Achalasia tissue exhibited an increase in the expression of proteins involved in extracellular matrix turnover, apoptosis, proinflammatory and profibrogenic cytokines, and Tregs and Bregs versus controls ( P < 0.001 ).

Circulating Th22/Th17/Th2/Th1 percentage showed a significant increase versus healthy donors ( P < 0.01 ).

Type III achalasia patients exhibited the highest inflammatory response versus types I and II.

Prevalence of both anti-myenteric antibodies and HSV-1 infection in achalasia patients was 100% versus 0% in controls.

Our results suggest that achalasia is a disease with an important local and systemic inflammatory autoimmune component, associated with the presence of specific anti-myenteric autoantibodies, as well as HSV-1 infection.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Furuzawa-Carballeda, Janette& Aguilar-León, D.& Gamboa-Domínguez, A.& Valdovinos, Miguel A.& Nuñez-Álvarez, Carlos& Martín-del-Campo, L. A.…[et al.]. 2015. Achalasia—An Autoimmune Inflammatory Disease: A Cross-Sectional Study. Journal of Immunology Research،Vol. 2015, no. 2015, pp.1-18.
https://search.emarefa.net/detail/BIM-1068566

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Furuzawa-Carballeda, Janette…[et al.]. Achalasia—An Autoimmune Inflammatory Disease: A Cross-Sectional Study. Journal of Immunology Research No. 2015 (2015), pp.1-18.
https://search.emarefa.net/detail/BIM-1068566

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Furuzawa-Carballeda, Janette& Aguilar-León, D.& Gamboa-Domínguez, A.& Valdovinos, Miguel A.& Nuñez-Álvarez, Carlos& Martín-del-Campo, L. A.…[et al.]. Achalasia—An Autoimmune Inflammatory Disease: A Cross-Sectional Study. Journal of Immunology Research. 2015. Vol. 2015, no. 2015, pp.1-18.
https://search.emarefa.net/detail/BIM-1068566

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1068566