Achalasia—An Autoimmune Inflammatory Disease: A Cross-Sectional Study
المؤلفون المشاركون
Valdovinos, Miguel A.
Aguilar-León, D.
Gamboa-Domínguez, A.
Martín-del-Campo, L. A.
Enríquez, A. B.
Coss-Adame, E.
Svarch, A. E.
Flores-Nájera, A.
Villa-Baños, A.
Ceballos, J. C.
Nuñez-Álvarez, Carlos
Torres-Villalobos, Gonzalo
Furuzawa-Carballeda, Janette
المصدر
Journal of Immunology Research
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-18، 18ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-05-20
دولة النشر
مصر
عدد الصفحات
18
التخصصات الرئيسية
الملخص EN
Idiopathic achalasia is a disease of unknown etiology.
The loss of myenteric plexus associated with inflammatory infiltrates and autoantibodies support the hypothesis of an autoimmune mechanism.
Thirty-two patients diagnosed by high-resolution manometry with achalasia were included.
Twenty-six specimens from lower esophageal sphincter muscle were compared with 5 esophagectomy biopsies (control).
Immunohistochemical (biopsies) and flow cytometry (peripheral blood) analyses were performed.
Circulating anti-myenteric autoantibodies were evaluated by indirect immunofluorescence.
Herpes simplex virus-1 (HSV-1) infection was determined by in situ hybridization, RT-PCR, and immunohistochemistry.
Histopathological analysis showed capillaritis (51%), plexitis (23%), nerve hypertrophy (16%), venulitis (7%), and fibrosis (3%).
Achalasia tissue exhibited an increase in the expression of proteins involved in extracellular matrix turnover, apoptosis, proinflammatory and profibrogenic cytokines, and Tregs and Bregs versus controls ( P < 0.001 ).
Circulating Th22/Th17/Th2/Th1 percentage showed a significant increase versus healthy donors ( P < 0.01 ).
Type III achalasia patients exhibited the highest inflammatory response versus types I and II.
Prevalence of both anti-myenteric antibodies and HSV-1 infection in achalasia patients was 100% versus 0% in controls.
Our results suggest that achalasia is a disease with an important local and systemic inflammatory autoimmune component, associated with the presence of specific anti-myenteric autoantibodies, as well as HSV-1 infection.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Furuzawa-Carballeda, Janette& Aguilar-León, D.& Gamboa-Domínguez, A.& Valdovinos, Miguel A.& Nuñez-Álvarez, Carlos& Martín-del-Campo, L. A.…[et al.]. 2015. Achalasia—An Autoimmune Inflammatory Disease: A Cross-Sectional Study. Journal of Immunology Research،Vol. 2015, no. 2015, pp.1-18.
https://search.emarefa.net/detail/BIM-1068566
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Furuzawa-Carballeda, Janette…[et al.]. Achalasia—An Autoimmune Inflammatory Disease: A Cross-Sectional Study. Journal of Immunology Research No. 2015 (2015), pp.1-18.
https://search.emarefa.net/detail/BIM-1068566
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Furuzawa-Carballeda, Janette& Aguilar-León, D.& Gamboa-Domínguez, A.& Valdovinos, Miguel A.& Nuñez-Álvarez, Carlos& Martín-del-Campo, L. A.…[et al.]. Achalasia—An Autoimmune Inflammatory Disease: A Cross-Sectional Study. Journal of Immunology Research. 2015. Vol. 2015, no. 2015, pp.1-18.
https://search.emarefa.net/detail/BIM-1068566
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1068566
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر