Expansion of Circulating T Follicular Helper Cells in Children with Acute Henoch-Schönlein Purpura
المؤلفون المشاركون
Xie, Jue
Liu, Yan
Wang, Lei
Ruan, Guoxiang
Yuan, Huiming
Fang, Hong
Wu, Jianyong
Cui, Dawei
المصدر
Journal of Immunology Research
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-09-28
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Henoch-Schönlein purpura (HSP) is a common systemic small vessel vasculitis in children with disorder autoimmune responses.
T follicular helper (TFH) cells play crucial roles in regulating immune responses.
The aim of our study was to investigate the probable role of TFH cells in the pathogenesis of children with HSP.
In this study, the frequency of circulating CXCR5+CD4+TFH cells with inducible costimulator (ICOS) expression in the children with acute HSP was significantly higher than that in healthy controls (HCs) but not CXCR5+CD4+TFH cells with programmed death-1 (PD-1) expression.
Moreover, serum levels of IL-21 and IL-6 cytokines, IgA, and C3 in HSP children were also significantly higher than those in HCs.
A positive correlation was observed between the frequencies of circulating ICOS+CXCR5+CD4+TFH cells and the serum IL-21 or IgA levels of acute HSP children, respectively.
Additionally, the mRNA expression levels of interleukin- (IL-) 21, IL-6, and transcriptional factors (B-cell lymphoma-6, Bcl-6) were also significantly increased in peripheral blood from acute HSP children compared to HCs.
Taken together, these findings suggest that TFH cells and associated molecules might play critical roles in the pathogenesis of HSP, which are possible therapeutic targets in HSP children.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Xie, Jue& Liu, Yan& Wang, Lei& Ruan, Guoxiang& Yuan, Huiming& Fang, Hong…[et al.]. 2015. Expansion of Circulating T Follicular Helper Cells in Children with Acute Henoch-Schönlein Purpura. Journal of Immunology Research،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1068576
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Xie, Jue…[et al.]. Expansion of Circulating T Follicular Helper Cells in Children with Acute Henoch-Schönlein Purpura. Journal of Immunology Research No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1068576
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Xie, Jue& Liu, Yan& Wang, Lei& Ruan, Guoxiang& Yuan, Huiming& Fang, Hong…[et al.]. Expansion of Circulating T Follicular Helper Cells in Children with Acute Henoch-Schönlein Purpura. Journal of Immunology Research. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1068576
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1068576
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر