Expansion of Circulating T Follicular Helper Cells in Children with Acute Henoch-Schönlein Purpura
Joint Authors
Xie, Jue
Liu, Yan
Wang, Lei
Ruan, Guoxiang
Yuan, Huiming
Fang, Hong
Wu, Jianyong
Cui, Dawei
Source
Journal of Immunology Research
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-09-28
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Henoch-Schönlein purpura (HSP) is a common systemic small vessel vasculitis in children with disorder autoimmune responses.
T follicular helper (TFH) cells play crucial roles in regulating immune responses.
The aim of our study was to investigate the probable role of TFH cells in the pathogenesis of children with HSP.
In this study, the frequency of circulating CXCR5+CD4+TFH cells with inducible costimulator (ICOS) expression in the children with acute HSP was significantly higher than that in healthy controls (HCs) but not CXCR5+CD4+TFH cells with programmed death-1 (PD-1) expression.
Moreover, serum levels of IL-21 and IL-6 cytokines, IgA, and C3 in HSP children were also significantly higher than those in HCs.
A positive correlation was observed between the frequencies of circulating ICOS+CXCR5+CD4+TFH cells and the serum IL-21 or IgA levels of acute HSP children, respectively.
Additionally, the mRNA expression levels of interleukin- (IL-) 21, IL-6, and transcriptional factors (B-cell lymphoma-6, Bcl-6) were also significantly increased in peripheral blood from acute HSP children compared to HCs.
Taken together, these findings suggest that TFH cells and associated molecules might play critical roles in the pathogenesis of HSP, which are possible therapeutic targets in HSP children.
American Psychological Association (APA)
Xie, Jue& Liu, Yan& Wang, Lei& Ruan, Guoxiang& Yuan, Huiming& Fang, Hong…[et al.]. 2015. Expansion of Circulating T Follicular Helper Cells in Children with Acute Henoch-Schönlein Purpura. Journal of Immunology Research،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1068576
Modern Language Association (MLA)
Xie, Jue…[et al.]. Expansion of Circulating T Follicular Helper Cells in Children with Acute Henoch-Schönlein Purpura. Journal of Immunology Research No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1068576
American Medical Association (AMA)
Xie, Jue& Liu, Yan& Wang, Lei& Ruan, Guoxiang& Yuan, Huiming& Fang, Hong…[et al.]. Expansion of Circulating T Follicular Helper Cells in Children with Acute Henoch-Schönlein Purpura. Journal of Immunology Research. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1068576
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1068576