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Correlation between Genetic Variations and Serum Level of Interleukin 28B with Virus Genotypes and Disease Progression in Chronic Hepatitis C Virus Infection
المؤلفون المشاركون
Albenmousa, Ali
Al-Hamoudi, Waleed
Alswat, Khalid A.
Khalaf, Nisreen
Viswan, Nisha
al-Anazi, Mashael R.
al-Qahtani, Ahmed A.
al-Ashgar, Hamad I.
Sanai, Faisal M.
al-Ahdal, Muhammad N.
Khan, Mohammed Q.
Abdo, Ayman A.
المصدر
Journal of Immunology Research
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-02-25
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Recent studies have demonstrated that polymorphisms near the interleukin-28B (IL-28B) gene could predict the response to Peg-IFN-a/RBV combination therapy in HCV-infected patients.
The aim of the study was to correlate the serum level of IL28B in HCV-infected patients with virus genotype/subgenotype and disease progression.
IL28B serum level was detected and variations at five single nucleotide polymorphisms (SNPs) in IL28B gene region were genotyped and analyzed.
The variation of IL28B genetic polymorphisms was found to be strongly associated with HCV infection when healthy control group was compared to HCV-infected patients with all P values <0.0001.
Functional analysis revealed that subjects carrying rs8099917-GG genotype had higher serum level of IL28B than those with GT or TT genotypes (P=0.04).
Also, patients who were presented with cirrhosis (Cirr) only or with cirrhosis plus hepatocellular carcinoma (Cirr+HCC) had higher levels of serum IL28B when compared to chronic HCV-infected patients (P=0.005 and 0.003, resp.).
No significant association was found when serum levels of IL28B were compared to virus genotypes/subgenotypes.
This study indicates that variation at SNP rs8099917 could predict the serum levels of IL28B in HCV-infected patients.
Furthermore, IL28B serum level may serve as a useful marker for the development of HCV-associated sequelae.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
al-Qahtani, Ahmed A.& al-Anazi, Mashael R.& Abdo, Ayman A.& Sanai, Faisal M.& Al-Hamoudi, Waleed& Alswat, Khalid A.…[et al.]. 2015. Correlation between Genetic Variations and Serum Level of Interleukin 28B with Virus Genotypes and Disease Progression in Chronic Hepatitis C Virus Infection. Journal of Immunology Research،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1068593
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
al-Qahtani, Ahmed A.…[et al.]. Correlation between Genetic Variations and Serum Level of Interleukin 28B with Virus Genotypes and Disease Progression in Chronic Hepatitis C Virus Infection. Journal of Immunology Research No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1068593
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
al-Qahtani, Ahmed A.& al-Anazi, Mashael R.& Abdo, Ayman A.& Sanai, Faisal M.& Al-Hamoudi, Waleed& Alswat, Khalid A.…[et al.]. Correlation between Genetic Variations and Serum Level of Interleukin 28B with Virus Genotypes and Disease Progression in Chronic Hepatitis C Virus Infection. Journal of Immunology Research. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1068593
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1068593
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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