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Correlation between Genetic Variations and Serum Level of Interleukin 28B with Virus Genotypes and Disease Progression in Chronic Hepatitis C Virus Infection
Joint Authors
Albenmousa, Ali
Al-Hamoudi, Waleed
Alswat, Khalid A.
Khalaf, Nisreen
Viswan, Nisha
al-Anazi, Mashael R.
al-Qahtani, Ahmed A.
al-Ashgar, Hamad I.
Sanai, Faisal M.
al-Ahdal, Muhammad N.
Khan, Mohammed Q.
Abdo, Ayman A.
Source
Journal of Immunology Research
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-02-25
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Recent studies have demonstrated that polymorphisms near the interleukin-28B (IL-28B) gene could predict the response to Peg-IFN-a/RBV combination therapy in HCV-infected patients.
The aim of the study was to correlate the serum level of IL28B in HCV-infected patients with virus genotype/subgenotype and disease progression.
IL28B serum level was detected and variations at five single nucleotide polymorphisms (SNPs) in IL28B gene region were genotyped and analyzed.
The variation of IL28B genetic polymorphisms was found to be strongly associated with HCV infection when healthy control group was compared to HCV-infected patients with all P values <0.0001.
Functional analysis revealed that subjects carrying rs8099917-GG genotype had higher serum level of IL28B than those with GT or TT genotypes (P=0.04).
Also, patients who were presented with cirrhosis (Cirr) only or with cirrhosis plus hepatocellular carcinoma (Cirr+HCC) had higher levels of serum IL28B when compared to chronic HCV-infected patients (P=0.005 and 0.003, resp.).
No significant association was found when serum levels of IL28B were compared to virus genotypes/subgenotypes.
This study indicates that variation at SNP rs8099917 could predict the serum levels of IL28B in HCV-infected patients.
Furthermore, IL28B serum level may serve as a useful marker for the development of HCV-associated sequelae.
American Psychological Association (APA)
al-Qahtani, Ahmed A.& al-Anazi, Mashael R.& Abdo, Ayman A.& Sanai, Faisal M.& Al-Hamoudi, Waleed& Alswat, Khalid A.…[et al.]. 2015. Correlation between Genetic Variations and Serum Level of Interleukin 28B with Virus Genotypes and Disease Progression in Chronic Hepatitis C Virus Infection. Journal of Immunology Research،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1068593
Modern Language Association (MLA)
al-Qahtani, Ahmed A.…[et al.]. Correlation between Genetic Variations and Serum Level of Interleukin 28B with Virus Genotypes and Disease Progression in Chronic Hepatitis C Virus Infection. Journal of Immunology Research No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1068593
American Medical Association (AMA)
al-Qahtani, Ahmed A.& al-Anazi, Mashael R.& Abdo, Ayman A.& Sanai, Faisal M.& Al-Hamoudi, Waleed& Alswat, Khalid A.…[et al.]. Correlation between Genetic Variations and Serum Level of Interleukin 28B with Virus Genotypes and Disease Progression in Chronic Hepatitis C Virus Infection. Journal of Immunology Research. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1068593
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1068593