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IL-31 Is Overexpressed in Lichen Planus but Its Level Does Not Correlate with Pruritus Severity
المؤلفون المشاركون
Welz-Kubiak, Kalina
Reich, Adam
Kobuszewska, Anna
المصدر
Journal of Immunology Research
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-02-03
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Background.
Pruritus is one of the major features of lichen planus (LP); however, its pathogenesis remains largely unknown.
Objective.
The aim of our study was to analyze the role of IL-31 in the pathogenesis of pruritus in LP.
Materials and Methods.
The study group included 22 patients with LP.
Control group consisted of 14 healthy volunteers.
All subjects underwent thorough examination.
Pruritus severity was evaluated with the visual analogue scale (VAS) and the 12-item Itch Questionnaire.
IL-31 expression in the skin was assessed using semiquantitative immunofluorescence analysis.
Results.
Pruritus maximal intensity according to VAS was 6.5 ± 2.7 points and according to the 12-item Itch Questionnaire 6.9 ± 2.8 points.
Lesional LP skin showed significantly higher IL-31 expression compared to healthy skin ( P < 0.001 ).
The most abundant immunofluorescence was observed within granular layer.
However, there was no correlation between expression of IL-31 and pruritus intensity assessed according to VAS ( VAS max : ρ = − 0.08 , P = 0.73 ), as well as 12-item Itch Questionnaire: ρ = − 0.11 , P = 0.65 .
Conclusions.
Pruritus is a very common symptom of LP.
For the first time we have demonstrated that IL-31 is overexpressed in the lesional skin of LP but its expression does not correlate with intensity of pruritus.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Welz-Kubiak, Kalina& Kobuszewska, Anna& Reich, Adam. 2015. IL-31 Is Overexpressed in Lichen Planus but Its Level Does Not Correlate with Pruritus Severity. Journal of Immunology Research،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1068621
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Welz-Kubiak, Kalina…[et al.]. IL-31 Is Overexpressed in Lichen Planus but Its Level Does Not Correlate with Pruritus Severity. Journal of Immunology Research No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1068621
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Welz-Kubiak, Kalina& Kobuszewska, Anna& Reich, Adam. IL-31 Is Overexpressed in Lichen Planus but Its Level Does Not Correlate with Pruritus Severity. Journal of Immunology Research. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1068621
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1068621
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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