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IL-31 Is Overexpressed in Lichen Planus but Its Level Does Not Correlate with Pruritus Severity
Joint Authors
Welz-Kubiak, Kalina
Reich, Adam
Kobuszewska, Anna
Source
Journal of Immunology Research
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-02-03
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
Pruritus is one of the major features of lichen planus (LP); however, its pathogenesis remains largely unknown.
Objective.
The aim of our study was to analyze the role of IL-31 in the pathogenesis of pruritus in LP.
Materials and Methods.
The study group included 22 patients with LP.
Control group consisted of 14 healthy volunteers.
All subjects underwent thorough examination.
Pruritus severity was evaluated with the visual analogue scale (VAS) and the 12-item Itch Questionnaire.
IL-31 expression in the skin was assessed using semiquantitative immunofluorescence analysis.
Results.
Pruritus maximal intensity according to VAS was 6.5 ± 2.7 points and according to the 12-item Itch Questionnaire 6.9 ± 2.8 points.
Lesional LP skin showed significantly higher IL-31 expression compared to healthy skin ( P < 0.001 ).
The most abundant immunofluorescence was observed within granular layer.
However, there was no correlation between expression of IL-31 and pruritus intensity assessed according to VAS ( VAS max : ρ = − 0.08 , P = 0.73 ), as well as 12-item Itch Questionnaire: ρ = − 0.11 , P = 0.65 .
Conclusions.
Pruritus is a very common symptom of LP.
For the first time we have demonstrated that IL-31 is overexpressed in the lesional skin of LP but its expression does not correlate with intensity of pruritus.
American Psychological Association (APA)
Welz-Kubiak, Kalina& Kobuszewska, Anna& Reich, Adam. 2015. IL-31 Is Overexpressed in Lichen Planus but Its Level Does Not Correlate with Pruritus Severity. Journal of Immunology Research،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1068621
Modern Language Association (MLA)
Welz-Kubiak, Kalina…[et al.]. IL-31 Is Overexpressed in Lichen Planus but Its Level Does Not Correlate with Pruritus Severity. Journal of Immunology Research No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1068621
American Medical Association (AMA)
Welz-Kubiak, Kalina& Kobuszewska, Anna& Reich, Adam. IL-31 Is Overexpressed in Lichen Planus but Its Level Does Not Correlate with Pruritus Severity. Journal of Immunology Research. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1068621
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1068621