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Exposure of Monocytes to Lipoarabinomannan Promotes Their Differentiation into Functionally and Phenotypically Immature Macrophages
المؤلفون المشاركون
Chávez-Galán, Leslie
Ocaña-Guzmán, Ranferi
Torre-Bouscoulet, Luis
García-de-Alba, Carolina
Sada-Ovalle, Isabel
المصدر
Journal of Immunology Research
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-16، 16ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-08-11
دولة النشر
مصر
عدد الصفحات
16
التخصصات الرئيسية
الملخص EN
Lipoarabinomannan (LAM) is a lipid virulence factor secreted by Mycobacterium tuberculosis (Mtb), the etiologic agent of tuberculosis.
LAM can be measured in the urine or serum of tuberculosis patients (TB-patients).
Circulating monocytes are the precursor cells of alveolar macrophages and might be exposed to LAM in patients with active TB.
We speculated that exposing monocytes to LAM could produce phenotypically and functionally immature macrophages.
To test our hypothesis, human monocytes were stimulated with LAM (24–120 hours) and various readouts were measured.
The study showed that when monocytes were exposed to LAM, the frequency of CD68+, CD33+, and CD86+ macrophages decreased, suggesting that monocyte differentiation into mature macrophages was affected.
Regarding functionality markers, TLR2+ and TLR4+ macrophages also decreased, but the percentage of MMR+ expression did not change.
LAM-exposed monocytes generated macrophages that were less efficient in producing proinflammatory cytokines such as TNF- α and IFN- γ ; however, their phagocytic capacity was not modified.
Taken together, these data indicate that LAM exposure influenced monocyte differentiation and produced poorly functional macrophages with a different phenotype.
These results may help us understand how mycobacteria can limit the quality of the innate and adaptive immune responses.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chávez-Galán, Leslie& Ocaña-Guzmán, Ranferi& Torre-Bouscoulet, Luis& García-de-Alba, Carolina& Sada-Ovalle, Isabel. 2015. Exposure of Monocytes to Lipoarabinomannan Promotes Their Differentiation into Functionally and Phenotypically Immature Macrophages. Journal of Immunology Research،Vol. 2015, no. 2015, pp.1-16.
https://search.emarefa.net/detail/BIM-1068663
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chávez-Galán, Leslie…[et al.]. Exposure of Monocytes to Lipoarabinomannan Promotes Their Differentiation into Functionally and Phenotypically Immature Macrophages. Journal of Immunology Research No. 2015 (2015), pp.1-16.
https://search.emarefa.net/detail/BIM-1068663
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chávez-Galán, Leslie& Ocaña-Guzmán, Ranferi& Torre-Bouscoulet, Luis& García-de-Alba, Carolina& Sada-Ovalle, Isabel. Exposure of Monocytes to Lipoarabinomannan Promotes Their Differentiation into Functionally and Phenotypically Immature Macrophages. Journal of Immunology Research. 2015. Vol. 2015, no. 2015, pp.1-16.
https://search.emarefa.net/detail/BIM-1068663
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1068663
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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