Increased Frequency of CD4+ CD25+ FoxP3+ T Regulatory Cells in Pulmonary Tuberculosis Patients Undergoing Specific Treatment and Its Relationship with Their Immune-Endocrine Profile
المؤلفون المشاركون
Bottasso, Oscar Adelmo
Díaz, Ariana
Santucci, Natalia
Bongiovanni, Bettina
D’Attilio, Luciano
Massoni, Claudia
Lioi, Susana
Radcliffe, Stella
Dídoli, Griselda
Bay, María Luisa
المصدر
Journal of Immunology Research
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-04-19
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Tuberculosis (TB) is a major health problem requiring an appropriate cell immune response (IR) to be controlled.
Since regulatory T cells (Tregs) are relevant in IR regulation, we analyzed Tregs variations throughout the course of TB treatment and its relationship with changes in immune-endocrine mediators dealing with disease immunopathology.
The cohort was composed of 41 adult patients, 20 of them completing treatment and follow-up.
Patients were bled at diagnosis (T0) and at 2 (T2), 4 (T4), 6 (T6), and 9 months following treatment initiation.
Twenty-four age- and sex-matched healthy controls (HCo) were also included.
Tregs (flow cytometry) from TB patients were increased at T0 (versus HCo P<0.05), showing even higher values at T2 (versus T0 P<0.01) and T4 (versus T0 P<0.001).
While IL-6, IFN-γ, TGF-β (ELISA), and Cortisol (electrochemiluminescence, EQ) were augmented, DHEA-S (EQ) levels were diminished at T0 with respect to HCo, with cytokines and Cortisol returning to normal values at T9.
Tregs correlated positively with IFN-γ (R=0.868, P<0.05) at T2 and negatively at T4 (R=-0.795, P<0.05).
Lowered levels of proinflammatory cytokines together with an increased frequency of Tregs of patients undergoing specific treatment might reflect a downmodulatory effect of these cells on the accompanying inflammation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Díaz, Ariana& Santucci, Natalia& Bongiovanni, Bettina& D’Attilio, Luciano& Massoni, Claudia& Lioi, Susana…[et al.]. 2015. Increased Frequency of CD4+ CD25+ FoxP3+ T Regulatory Cells in Pulmonary Tuberculosis Patients Undergoing Specific Treatment and Its Relationship with Their Immune-Endocrine Profile. Journal of Immunology Research،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1068664
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Díaz, Ariana…[et al.]. Increased Frequency of CD4+ CD25+ FoxP3+ T Regulatory Cells in Pulmonary Tuberculosis Patients Undergoing Specific Treatment and Its Relationship with Their Immune-Endocrine Profile. Journal of Immunology Research No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1068664
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Díaz, Ariana& Santucci, Natalia& Bongiovanni, Bettina& D’Attilio, Luciano& Massoni, Claudia& Lioi, Susana…[et al.]. Increased Frequency of CD4+ CD25+ FoxP3+ T Regulatory Cells in Pulmonary Tuberculosis Patients Undergoing Specific Treatment and Its Relationship with Their Immune-Endocrine Profile. Journal of Immunology Research. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1068664
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1068664
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر