Impact of Silver and Iron Nanoparticle Exposure on Cholesterol Uptake by Macrophages
المؤلفون المشاركون
Shannahan, Jonathan H.
Sowrirajan, Hari
Persaud, Indushekhar
Podila, Ramakrishna
Brown, Jared M.
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-10-18
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Macrophages are central to the development of atherosclerosis by absorbing lipids, promoting inflammation, and increasing plaque deposition.
Nanoparticles (NPs) are becoming increasingly common in biomedical applications thereby increasing exposure to the immune and vascular systems.
This project investigated the influence of NPs on macrophage function and specifically cholesterol uptake.
Macrophages were exposed to 20 nm silver NPs (AgNPs), 110 nm AgNPs, or 20 nm Fe3O4 NPs for 2 h and NP uptake, cytotoxicity, and subsequent uptake of fluorescently labeled cholesterol were assessed.
Macrophage uptake of NPs did not induce cytotoxicity at concentrations utilized (25 μg/mL); however, macrophage exposure to 20 nm AgNPs reduced subsequent uptake of cholesterol.
Further, we assessed the impact of a cholesterol-rich environment on macrophage function following NP exposure.
In these sets of experiments, macrophages internalized NPs, exhibited no cytotoxicity, and altered cholesterol uptake.
Alterations in the expression of scavenger receptor-B1 following NP exposure, which likely influences cholesterol uptake, were observed.
Overall, NPs alter cholesterol uptake, which may have implications in the progression of vascular or immune mediated diseases.
Therefore, for the safe development of NPs for biomedical applications, it is necessary to understand their impact on cellular function and biological interactions in underlying disease environments.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Shannahan, Jonathan H.& Sowrirajan, Hari& Persaud, Indushekhar& Podila, Ramakrishna& Brown, Jared M.. 2015. Impact of Silver and Iron Nanoparticle Exposure on Cholesterol Uptake by Macrophages. Journal of Nanomaterials،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1068740
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Shannahan, Jonathan H.…[et al.]. Impact of Silver and Iron Nanoparticle Exposure on Cholesterol Uptake by Macrophages. Journal of Nanomaterials No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1068740
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Shannahan, Jonathan H.& Sowrirajan, Hari& Persaud, Indushekhar& Podila, Ramakrishna& Brown, Jared M.. Impact of Silver and Iron Nanoparticle Exposure on Cholesterol Uptake by Macrophages. Journal of Nanomaterials. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1068740
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1068740
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر