Rapid and Sensitive Detection of Lung Cancer Biomarker Using Nanoporous Biosensor Based on Localized Surface Plasmon Resonance Coupled with Interferometry
المؤلفون المشاركون
Lee, Jae-Sung
Kim, Sae-Wan
Jang, Eun-Yoon
Kang, Byoung-Ho
Lee, Sang-Won
Sai-Anand, Gopalan
Lee, Seung-Ha
Kwon, Dae-Hyuk
Kang, Shin-Won
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-10-19
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
We propose a nanobiosensor to evaluate a lung cancer-specific biomarker.
The nanobiosensor is based on an anodic aluminum oxide (AAO) chip and functions on the principles of localized surface plasmon resonance (LSPR) and interferometry.
The pore-depth of the fabricated nanoporous AAO chip was 1 µm and was obtained using a two-step electrochemical anodization process.
The sensor chip is sensitive to the refractive index (RI) changes of the surrounding medium and also provides simple and label-free detection when specific antibodies are immobilized on the gold-deposited surface of the AAO chip.
In order to confirm the effectiveness of the sensor, the antibodies were immobilized on the surface of the AAO chip, and the lung cancer-specific biomarker was applied atop of the immobilized-antibody layer using the self-assembled monolayer method.
The nanoporous AAO chip was used as a sensor system to detect serum amyloid A1, which is a lung cancer-specific biomarker.
The specific reaction of the antigen-antibody contributes to the change in the RI.
This in turn causes a shift in the resonance spectrum in the refractive interference pattern.
The limit of detection (LOD) was found to be 100 ag/mL and the biosensor had high sensitivity over a wide concentration range.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lee, Jae-Sung& Kim, Sae-Wan& Jang, Eun-Yoon& Kang, Byoung-Ho& Lee, Sang-Won& Sai-Anand, Gopalan…[et al.]. 2015. Rapid and Sensitive Detection of Lung Cancer Biomarker Using Nanoporous Biosensor Based on Localized Surface Plasmon Resonance Coupled with Interferometry. Journal of Nanomaterials،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1068799
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lee, Jae-Sung…[et al.]. Rapid and Sensitive Detection of Lung Cancer Biomarker Using Nanoporous Biosensor Based on Localized Surface Plasmon Resonance Coupled with Interferometry. Journal of Nanomaterials No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1068799
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lee, Jae-Sung& Kim, Sae-Wan& Jang, Eun-Yoon& Kang, Byoung-Ho& Lee, Sang-Won& Sai-Anand, Gopalan…[et al.]. Rapid and Sensitive Detection of Lung Cancer Biomarker Using Nanoporous Biosensor Based on Localized Surface Plasmon Resonance Coupled with Interferometry. Journal of Nanomaterials. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1068799
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1068799
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر