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Electrospinning Preparation of Timosaponin B-II-Loaded PLLA Nanofibers and Their Antitumor Recurrence Activities In Vivo
المؤلفون المشاركون
Huo, Zhonghua
Qiu, Yan
Chu, Zhuling
Yin, Peng
Lu, Wenquan
Yan, Yijia
Wan, Na
Chen, Zhilong
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-05-07
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Poly(L-lactic)-acid (PLLA) as a drug carrier and a water-soluble drug timosaponin B-II (TB-II) as a model drug were selected to prepare drug-loaded nanofibers by electrospinning.
The average diameters of pure PLLA nanofibers and TB-II-loaded nanofibers were 212.5 ± 68.5, 219.7 ± 57.8, 232.8 ± 66.9, and 232.9 ± 97.7 nm, respectively.
DSC and XRD results demonstrated that TB-II was well incorporated into the nanofibers in an amorphous state.
FI-TR spectroscopy indicated that TB-II had good compatibility with PLLA.
In vitro release studies showed that TB-II was rapidly released from the nanofibers within 6 h, followed by a gradual release for long time.
In vivo biosafety test revealed no noticeable toxicity of these TB-II nanofibers.
The TB-II released from the nanofibers had obvious inhibition effect against human hepatocellular carcinoma SMMC 7721 cells both in vivo and in vitro.
It was confirmed that the TB-II-loaded nanofibers were a sustained delivery system which could effectively inhibit the tumor growth and recurrence after surgery.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Huo, Zhonghua& Qiu, Yan& Chu, Zhuling& Yin, Peng& Lu, Wenquan& Yan, Yijia…[et al.]. 2015. Electrospinning Preparation of Timosaponin B-II-Loaded PLLA Nanofibers and Their Antitumor Recurrence Activities In Vivo. Journal of Nanomaterials،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1068950
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Huo, Zhonghua…[et al.]. Electrospinning Preparation of Timosaponin B-II-Loaded PLLA Nanofibers and Their Antitumor Recurrence Activities In Vivo. Journal of Nanomaterials No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1068950
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Huo, Zhonghua& Qiu, Yan& Chu, Zhuling& Yin, Peng& Lu, Wenquan& Yan, Yijia…[et al.]. Electrospinning Preparation of Timosaponin B-II-Loaded PLLA Nanofibers and Their Antitumor Recurrence Activities In Vivo. Journal of Nanomaterials. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1068950
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1068950
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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