Electrospinning Preparation of Timosaponin B-II-Loaded PLLA Nanofibers and Their Antitumor Recurrence Activities In Vivo
Joint Authors
Huo, Zhonghua
Qiu, Yan
Chu, Zhuling
Yin, Peng
Lu, Wenquan
Yan, Yijia
Wan, Na
Chen, Zhilong
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-07
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Poly(L-lactic)-acid (PLLA) as a drug carrier and a water-soluble drug timosaponin B-II (TB-II) as a model drug were selected to prepare drug-loaded nanofibers by electrospinning.
The average diameters of pure PLLA nanofibers and TB-II-loaded nanofibers were 212.5 ± 68.5, 219.7 ± 57.8, 232.8 ± 66.9, and 232.9 ± 97.7 nm, respectively.
DSC and XRD results demonstrated that TB-II was well incorporated into the nanofibers in an amorphous state.
FI-TR spectroscopy indicated that TB-II had good compatibility with PLLA.
In vitro release studies showed that TB-II was rapidly released from the nanofibers within 6 h, followed by a gradual release for long time.
In vivo biosafety test revealed no noticeable toxicity of these TB-II nanofibers.
The TB-II released from the nanofibers had obvious inhibition effect against human hepatocellular carcinoma SMMC 7721 cells both in vivo and in vitro.
It was confirmed that the TB-II-loaded nanofibers were a sustained delivery system which could effectively inhibit the tumor growth and recurrence after surgery.
American Psychological Association (APA)
Huo, Zhonghua& Qiu, Yan& Chu, Zhuling& Yin, Peng& Lu, Wenquan& Yan, Yijia…[et al.]. 2015. Electrospinning Preparation of Timosaponin B-II-Loaded PLLA Nanofibers and Their Antitumor Recurrence Activities In Vivo. Journal of Nanomaterials،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1068950
Modern Language Association (MLA)
Huo, Zhonghua…[et al.]. Electrospinning Preparation of Timosaponin B-II-Loaded PLLA Nanofibers and Their Antitumor Recurrence Activities In Vivo. Journal of Nanomaterials No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1068950
American Medical Association (AMA)
Huo, Zhonghua& Qiu, Yan& Chu, Zhuling& Yin, Peng& Lu, Wenquan& Yan, Yijia…[et al.]. Electrospinning Preparation of Timosaponin B-II-Loaded PLLA Nanofibers and Their Antitumor Recurrence Activities In Vivo. Journal of Nanomaterials. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1068950
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1068950