Synthesis of Superparamagnetic Iron Oxide Nanoparticles Modified with MPEG-PEI via Photochemistry as New MRI Contrast Agent

المؤلفون المشاركون

Gu, Xiangling
Zhang, Yancong
Sun, Hanwen
Song, Xinfeng
Zhang, Lianying
Fu, Chunhua
Meng, Fanzong

المصدر

Journal of Nanomaterials

العدد

المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-6، 6ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2015-02-15

دولة النشر

مصر

عدد الصفحات

6

التخصصات الرئيسية

الكيمياء
هندسة مدنية

الملخص EN

Novel method for synthesis of superparamagnetic iron oxide nanoparticles (SPIONs) coated with polyethylenimine (PEI) and modified with poly(ethylene glycol) methyl ether (MPEG), MPEG-PEI-SPIONs, was developed.

PEI-SPIONs were successfully prepared in aqueous system via photochemistry, and their surface was modified with poly(ethylene glycol) methyl ether (MPEG).

The so-obtained MPEG-PEI-SPIONs had a uniform hydrodynamic particle size of 34 nm.

The successful coating of MPEG-PEI on the SPIONs was ascertained from FT-IR analysis, and the PEI and MPEG fractions in MPEG-PEI-SPIONs were calculated to account for 31% and 12%, respectively.

Magnetic measurement revealed that the saturated magnetization of MPEG-PEI-SPIONs reached 46 emu/g and the nanoparticles showed the characteristic of being superparamagnetic.

The stability experiment revealed that the MPEG-PEI modification improved the nanoparticles stability greatly.

T2 relaxation measurements showed that MPEG-PEI-SPIONs show similar R2 value to the PEI-SPIONs.

The T2-weighted magnetic resonance imaging (MRI) of MPEG-PEI-SPIONs showed that the magnetic resonance signal was enhanced significantly with increasing nanoparticle concentration in water.

These results indicated that the MPEG-PEI-SPIONs had great potential for application in MRI.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Zhang, Yancong& Zhang, Lianying& Song, Xinfeng& Gu, Xiangling& Sun, Hanwen& Fu, Chunhua…[et al.]. 2015. Synthesis of Superparamagnetic Iron Oxide Nanoparticles Modified with MPEG-PEI via Photochemistry as New MRI Contrast Agent. Journal of Nanomaterials،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1069005

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Zhang, Yancong…[et al.]. Synthesis of Superparamagnetic Iron Oxide Nanoparticles Modified with MPEG-PEI via Photochemistry as New MRI Contrast Agent. Journal of Nanomaterials No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1069005

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Zhang, Yancong& Zhang, Lianying& Song, Xinfeng& Gu, Xiangling& Sun, Hanwen& Fu, Chunhua…[et al.]. Synthesis of Superparamagnetic Iron Oxide Nanoparticles Modified with MPEG-PEI via Photochemistry as New MRI Contrast Agent. Journal of Nanomaterials. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1069005

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1069005