Synthesis of Superparamagnetic Iron Oxide Nanoparticles Modified with MPEG-PEI via Photochemistry as New MRI Contrast Agent
Joint Authors
Gu, Xiangling
Zhang, Yancong
Sun, Hanwen
Song, Xinfeng
Zhang, Lianying
Fu, Chunhua
Meng, Fanzong
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-02-15
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Novel method for synthesis of superparamagnetic iron oxide nanoparticles (SPIONs) coated with polyethylenimine (PEI) and modified with poly(ethylene glycol) methyl ether (MPEG), MPEG-PEI-SPIONs, was developed.
PEI-SPIONs were successfully prepared in aqueous system via photochemistry, and their surface was modified with poly(ethylene glycol) methyl ether (MPEG).
The so-obtained MPEG-PEI-SPIONs had a uniform hydrodynamic particle size of 34 nm.
The successful coating of MPEG-PEI on the SPIONs was ascertained from FT-IR analysis, and the PEI and MPEG fractions in MPEG-PEI-SPIONs were calculated to account for 31% and 12%, respectively.
Magnetic measurement revealed that the saturated magnetization of MPEG-PEI-SPIONs reached 46 emu/g and the nanoparticles showed the characteristic of being superparamagnetic.
The stability experiment revealed that the MPEG-PEI modification improved the nanoparticles stability greatly.
T2 relaxation measurements showed that MPEG-PEI-SPIONs show similar R2 value to the PEI-SPIONs.
The T2-weighted magnetic resonance imaging (MRI) of MPEG-PEI-SPIONs showed that the magnetic resonance signal was enhanced significantly with increasing nanoparticle concentration in water.
These results indicated that the MPEG-PEI-SPIONs had great potential for application in MRI.
American Psychological Association (APA)
Zhang, Yancong& Zhang, Lianying& Song, Xinfeng& Gu, Xiangling& Sun, Hanwen& Fu, Chunhua…[et al.]. 2015. Synthesis of Superparamagnetic Iron Oxide Nanoparticles Modified with MPEG-PEI via Photochemistry as New MRI Contrast Agent. Journal of Nanomaterials،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1069005
Modern Language Association (MLA)
Zhang, Yancong…[et al.]. Synthesis of Superparamagnetic Iron Oxide Nanoparticles Modified with MPEG-PEI via Photochemistry as New MRI Contrast Agent. Journal of Nanomaterials No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1069005
American Medical Association (AMA)
Zhang, Yancong& Zhang, Lianying& Song, Xinfeng& Gu, Xiangling& Sun, Hanwen& Fu, Chunhua…[et al.]. Synthesis of Superparamagnetic Iron Oxide Nanoparticles Modified with MPEG-PEI via Photochemistry as New MRI Contrast Agent. Journal of Nanomaterials. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1069005
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1069005