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Overexpression of Activation-Induced Cytidine Deaminase in MTX- and Age-Related Epstein-Barr Virus-Associated B-Cell Lymphoproliferative Disorders of the Head and Neck
المؤلفون المشاركون
Kikuchi, Kentaro
Ishige, Toshiyuki
Ide, Fumio
Ito, Yumi
Saito, Ichiro
Hoshino, Miyako
Inoue, Harumi
Miyazaki, Yuji
Nozaki, Tadashige
Kusama, Kaoru
Kojima, Masaru
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-03-05
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Recent research has shown that activation-induced cytidine deaminase (AID) triggers somatic hypermutation and recombination, in turn contributing to lymphomagenesis.
Such aberrant AID expression is seen in B-cell leukemia/lymphomas, including Burkitt lymphoma which is associated with c-myc translocation.
Moreover, Epstein-Barr virus (EBV) latent membrane protein-1 (LMP-1) increases genomic instability through early growth transcription response-1 (Egr-1) mediated upregulation of AID in B-cell lymphoma.
However, few clinicopathological studies have focused on AID expression in lymphoproliferative disorders (LPDs).
Therefore, we conducted an immunohistochemical study to investigate the relationship between AID and LMP-1 expression in LPDs (MTX-/Age-related EBV-associated), including diffuse large B-cell lymphomas (DLBCLs).
More intense AID expression was detected in LPDs (89.5%) than in DLBCLs (20.0%), and the expression of LMP-1 and EBER was more intense in LPDs (68.4% and 94.7%) than in DLBCLs (10.0% and 20.0%).
Furthermore, stronger Egr-1 expression was found in MTX/Age-EBV-LPDs (83.3%) than in DLBCLs (30.0%).
AID expression was significantly constitutively overexpressed in LPDs as compared with DLBCLs.
These results suggest that increased AID expression in LPDs may be one of the processes involved in lymphomagenesis, thereby further increasing the survival of genetically destabilized B-cells.
AID expression may be a useful indicator for differentiation between LPDs and DLBCLs.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kikuchi, Kentaro& Ishige, Toshiyuki& Ide, Fumio& Ito, Yumi& Saito, Ichiro& Hoshino, Miyako…[et al.]. 2015. Overexpression of Activation-Induced Cytidine Deaminase in MTX- and Age-Related Epstein-Barr Virus-Associated B-Cell Lymphoproliferative Disorders of the Head and Neck. Journal of Oncology،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1069577
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kikuchi, Kentaro…[et al.]. Overexpression of Activation-Induced Cytidine Deaminase in MTX- and Age-Related Epstein-Barr Virus-Associated B-Cell Lymphoproliferative Disorders of the Head and Neck. Journal of Oncology No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1069577
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kikuchi, Kentaro& Ishige, Toshiyuki& Ide, Fumio& Ito, Yumi& Saito, Ichiro& Hoshino, Miyako…[et al.]. Overexpression of Activation-Induced Cytidine Deaminase in MTX- and Age-Related Epstein-Barr Virus-Associated B-Cell Lymphoproliferative Disorders of the Head and Neck. Journal of Oncology. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1069577
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1069577
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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