Overexpression of Activation-Induced Cytidine Deaminase in MTX- and Age-Related Epstein-Barr Virus-Associated B-Cell Lymphoproliferative Disorders of the Head and Neck
Joint Authors
Kikuchi, Kentaro
Ishige, Toshiyuki
Ide, Fumio
Ito, Yumi
Saito, Ichiro
Hoshino, Miyako
Inoue, Harumi
Miyazaki, Yuji
Nozaki, Tadashige
Kusama, Kaoru
Kojima, Masaru
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-05
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Recent research has shown that activation-induced cytidine deaminase (AID) triggers somatic hypermutation and recombination, in turn contributing to lymphomagenesis.
Such aberrant AID expression is seen in B-cell leukemia/lymphomas, including Burkitt lymphoma which is associated with c-myc translocation.
Moreover, Epstein-Barr virus (EBV) latent membrane protein-1 (LMP-1) increases genomic instability through early growth transcription response-1 (Egr-1) mediated upregulation of AID in B-cell lymphoma.
However, few clinicopathological studies have focused on AID expression in lymphoproliferative disorders (LPDs).
Therefore, we conducted an immunohistochemical study to investigate the relationship between AID and LMP-1 expression in LPDs (MTX-/Age-related EBV-associated), including diffuse large B-cell lymphomas (DLBCLs).
More intense AID expression was detected in LPDs (89.5%) than in DLBCLs (20.0%), and the expression of LMP-1 and EBER was more intense in LPDs (68.4% and 94.7%) than in DLBCLs (10.0% and 20.0%).
Furthermore, stronger Egr-1 expression was found in MTX/Age-EBV-LPDs (83.3%) than in DLBCLs (30.0%).
AID expression was significantly constitutively overexpressed in LPDs as compared with DLBCLs.
These results suggest that increased AID expression in LPDs may be one of the processes involved in lymphomagenesis, thereby further increasing the survival of genetically destabilized B-cells.
AID expression may be a useful indicator for differentiation between LPDs and DLBCLs.
American Psychological Association (APA)
Kikuchi, Kentaro& Ishige, Toshiyuki& Ide, Fumio& Ito, Yumi& Saito, Ichiro& Hoshino, Miyako…[et al.]. 2015. Overexpression of Activation-Induced Cytidine Deaminase in MTX- and Age-Related Epstein-Barr Virus-Associated B-Cell Lymphoproliferative Disorders of the Head and Neck. Journal of Oncology،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1069577
Modern Language Association (MLA)
Kikuchi, Kentaro…[et al.]. Overexpression of Activation-Induced Cytidine Deaminase in MTX- and Age-Related Epstein-Barr Virus-Associated B-Cell Lymphoproliferative Disorders of the Head and Neck. Journal of Oncology No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1069577
American Medical Association (AMA)
Kikuchi, Kentaro& Ishige, Toshiyuki& Ide, Fumio& Ito, Yumi& Saito, Ichiro& Hoshino, Miyako…[et al.]. Overexpression of Activation-Induced Cytidine Deaminase in MTX- and Age-Related Epstein-Barr Virus-Associated B-Cell Lymphoproliferative Disorders of the Head and Neck. Journal of Oncology. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1069577
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1069577